INT329963

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.28
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL21) extracellular space (IL21) extracellular region (IL21)
plasma membrane (IL23R)
IL21 (Homo sapiens)
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 39 100.00 Very High Very High Very High
Multiple sclerosis 2 100.00 Very High Very High Very High
Crohn's disease 2 98.12 Very High Very High Very High
spinal inflammation 1 95.96 Very High Very High Very High
Arthritis 76 88.32 High High
Inflammation 2 81.28 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 39 100.00 Very High Very High Very High
Disease 14 100.00 Very High Very High Very High
Demyelinating Disease 2 100.00 Very High Very High Very High
Diabetes Mellitus 2 100.00 Very High Very High Very High
Celiac Disease 1 100.00 Very High Very High Very High
Autoimmune Disease 11 98.14 Very High Very High Very High
Inflammatory Bowel Disease 1 97.40 Very High Very High Very High
Low Back Pain 1 95.96 Very High Very High Very High
Juvenile Chronic Polyarthritis 72 89.92 High High
INFLAMMATION 1 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, more genetic risk factors were identified for common diseases in 2007 than had been collectively reported before that date.1 It is also interesting to note that evaluating the results from the study of one disease in other complex diseases can disclose common risk factors.1 Thus there has been detectable overlap of loci for autoimmune diseases, with examples such as a region on chromosome 4q27 that encodes the interleukin 2 (IL2) and IL21 genes, which is associated with susceptibility to coeliac disease, multiple sclerosis, type 1 diabetes and RA,2 3 and the IL23R region on 1p31 which has been associated with Crohn's disease,4 ulcerative colitis,4 psoriasis5 and ankylosing spondylitis.6
IL21 Binding (associated) of IL23R associated with spinal inflammation, autoimmune disease, crohn's disease, diabetes mellitus, rheumatoid arthritis, disease, multiple sclerosis, celiac disease and inflammatory bowel disease
1) Confidence 0.30 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 2.28 Pain Relevance 0.60

General Comments

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