INT3300

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 3
Speculated 11
Reported most in Abstract
Documents 179
Total Number 190
Disease Relevance 77.76
Pain Relevance 144.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
plasma 50
DRG 44
blood 15
spinal cord 14
sensory neurons 10
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1644 100.00 Very High Very High Very High
Nerve growth factor 589 100.00 Very High Very High Very High
substance P 202 100.00 Very High Very High Very High
Neuropeptide 175 100.00 Very High Very High Very High
dorsal root ganglion 156 100.00 Very High Very High Very High
nociceptor 98 100.00 Very High Very High Very High
Sciatic nerve 25 100.00 Very High Very High Very High
calcitonin gene related peptide 16 100.00 Very High Very High Very High
Morphine 97 99.98 Very High Very High Very High
Eae 31 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 321 100.00 Very High Very High Very High
Repression 6 100.00 Very High Very High Very High
Nociception 169 99.98 Very High Very High Very High
Immunization 5 99.98 Very High Very High Very High
Headache 250 99.92 Very High Very High Very High
Neuropathic Pain 53 99.92 Very High Very High Very High
Cancer Pain 5 99.92 Very High Very High Very High
Hyperalgesia 62 99.90 Very High Very High Very High
Cancer 35 99.90 Very High Very High Very High
Disease 94 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with capsaicin, a single injection or a second injection, prevented the increased in the expression of CGRP mRNA in DRG.
Positive_regulation (increased) of Gene_expression (expression) of CGRP mRNA in DRG associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.70 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12832107 Disease Relevance 0.23 Pain Relevance 0.91
An increase in the synthesis and release of calcitonin gene-related peptide in two-kidney, one-clip hypertensive rats.
Positive_regulation (increase) of Gene_expression (synthesis) of calcitonin gene-related peptide in kidney associated with hypertension and calcitonin gene-related peptide
2) Confidence 0.70 Published 2003 Journal Regul. Pept. Section Title Doc Link 12832107 Disease Relevance 0.25 Pain Relevance 0.64
Following injection of the bulbocavernosus/levator ani with extracts from castrated rats, the level of CGRP expression and the number of SNB motoneurons with alpha-CGRP message were increased.
Positive_regulation (increased) of Gene_expression (expression) of CGRP in motoneurons associated with calcitonin gene-related peptide
3) Confidence 0.70 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.23 Pain Relevance 0.62
Peripherally, these changes include increased expression of calcitonin gene-related peptide (CGRP) in trigeminal primary afferent neurons.
Positive_regulation (increased) of Gene_expression (expression) of calcitonin gene-related peptide in afferent neurons associated with calcitonin gene-related peptide
4) Confidence 0.70 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19438917 Disease Relevance 1.20 Pain Relevance 2.07
Depolarization stimulates initial calcitonin gene-related peptide expression by embryonic sensory neurons in vitro.
Positive_regulation (stimulates) of Gene_expression (expression) of calcitonin in sensory neurons associated with calcitonin gene-related peptide
5) Confidence 0.70 Published 1998 Journal J. Neurosci. Section Title Doc Link 9801368 Disease Relevance 0.53 Pain Relevance 0.93
Monophosphoryl lipid A caused a significant increase in the expression of alpha-CGRP mRNA, but not of beta-CGRP mRNA, concomitantly with an increase in plasma concentrations of CGRP, and the increased level of CGRP expression happened before stimulation of CGRP release.
Positive_regulation (increased) of Gene_expression (expression) of CGRP in plasma associated with calcitonin gene-related peptide
6) Confidence 0.70 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11834251 Disease Relevance 0 Pain Relevance 0.80
Overexpression of CGRP was also noted at 1 h after reperfusion.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CGRP
7) Confidence 0.70 Published 2009 Journal Anesthesiology Section Body Doc Link 19194162 Disease Relevance 0.16 Pain Relevance 0
Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat.
Positive_regulation (Increased) of Gene_expression (expression) of calcitonin gene-related peptide in dorsal root ganglia associated with calcitonin gene-related peptide
8) Confidence 0.69 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1281253 Disease Relevance 0.40 Pain Relevance 0.60
In conclusion, chronic administration of Rut can reduce blood pressure and relieve mesenteric artery hypertrophy in the 2K1C hypertensive rats, and the effects of Rut may be related to stimulation of CGRP synthesis and release.
Positive_regulation (stimulation) of Gene_expression (synthesis) of CGRP in blood associated with hypertrophy, hypertension and calcitonin gene-related peptide
9) Confidence 0.69 Published 2007 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18091582 Disease Relevance 0.68 Pain Relevance 0.34
Previous investigations have demonstrated that the hypotensive effect of rutaecarpine (Rut) is associated to stimulation of CGRP synthesis and release via activation of the vanilloid receptor subtype 1 (VR1) in the phenol-induced hypertensive rat.
Positive_regulation (stimulation) of Gene_expression (synthesis) of CGRP associated with vanilloid receptor subtype 1, hypertension, hypotension and calcitonin gene-related peptide
10) Confidence 0.69 Published 2007 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18091582 Disease Relevance 0.51 Pain Relevance 0.48
We found that rutaecarpine causes a sustained depressor action by stimulation of CGRP synthesis and release via activation of vanilloid receptor subtype 1 (VR1) in hypertensive rats, which reveals the therapeutic implications of VR1 agonists for treatment of hypertension.
Positive_regulation (stimulation) of Gene_expression (synthesis) of CGRP associated with vanilloid receptor subtype 1, hypertension, agonist and calcitonin gene-related peptide
11) Confidence 0.69 Published 2005 Journal Peptides Section Abstract Doc Link 16112410 Disease Relevance 0.98 Pain Relevance 0.78
The increase in CGRP expression preceded the increase in CGRP release.
Positive_regulation (increase) of Gene_expression (expression) of CGRP associated with calcitonin gene-related peptide
12) Confidence 0.69 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11919648 Disease Relevance 0 Pain Relevance 0.67
CONCLUSION: These results suggest, for the first time, that the hypotensive effect of Rut is mediated by stimulation of CGRP synthesis and release via activation of VR1 in the phenol-induced hypertensive rat.


Positive_regulation (stimulation) of Gene_expression (synthesis) of CGRP
13) Confidence 0.69 Published 2004 Journal J. Hypertens. Section Body Doc Link 15311112 Disease Relevance 0 Pain Relevance 0
In the spinal cord, CGRP expression was higher than normal 1 d after a sciatic nerve crush and increased during the next few days.
Positive_regulation (higher) of Gene_expression (expression) of CGRP in spinal cord associated with sciatic nerve, calcitonin gene-related peptide and spinal cord
14) Confidence 0.69 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7823160 Disease Relevance 0 Pain Relevance 0.76
Co-exposure with the peptide CGRP receptor antagonist CGRP8-37, SR140333 or nimesulide prevented the morphine-induced increase in the expression of CGRP immunoreactivity.
Positive_regulation (increase) of Gene_expression (expression) of CGRP associated with antagonist, morphine and calcitonin gene-related peptide
15) Confidence 0.68 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511336 Disease Relevance 0.24 Pain Relevance 2.18
Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons.
Positive_regulation (increase) of Gene_expression (expression) of CGRP in dorsal root ganglion associated with ganglion cysts, root ganglion neuron, tolerance, morphine and substance p
16) Confidence 0.68 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14511336 Disease Relevance 0.25 Pain Relevance 1.61
Follistatin blocked CGRP expression induced by serum or skin-conditioned medium, implicating transforming growth factor beta (TGFbeta) family members.
Positive_regulation (induced) of Gene_expression (expression) of CGRP in skin associated with calcitonin gene-related peptide
17) Confidence 0.68 Published 1999 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 10656256 Disease Relevance 0.61 Pain Relevance 0.76
Here, we examined whether acid activated the transient receptor potential vanilloid subtype 1 (Trpv1), a widely recognized acid-sensing nociceptor and subsequently increased CGRP expression.
Spec (whether) Positive_regulation (increased) of Gene_expression (expression) of CGRP in nociceptor associated with nociceptor and calcitonin gene-related peptide
18) Confidence 0.66 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.18 Pain Relevance 1.32
In organ cultures of DRG, acid (pH 5.5) elevated CGRP expression and the selective Trpv1 antagonist 5'-Iodoresiniferatoxin decreased it.
Positive_regulation (elevated) of Gene_expression (expression) of CGRP in DRG associated with dorsal root ganglion, antagonist and calcitonin gene-related peptide
19) Confidence 0.66 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.22 Pain Relevance 1.37
Knockdown of CREB by small interfering RNA or a dominant-negative form of CREB diminished acid-elevated CGRP expression.
Positive_regulation (elevated) of Gene_expression (expression) of CGRP associated with calcitonin gene-related peptide
20) Confidence 0.66 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.08 Pain Relevance 1.37

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