INT330014

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.08 Pain Relevance 0.04

HTLVR (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 16 81.56 adenocard 10 49.12 Inflammation 4 5.00 Neurotransmitter 4 5.00 imagery 4 5.00 Catecholamine 4 5.00 Spinal cord 2 5.00 Enkephalin 2 5.00 tolerance 2 5.00 wide dynamic range 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 8 77.28 Stress 8 22.64 Cancer 4 14.56 Htlv Types I And Ii 16 5.00 Infection 14 5.00 Disease 8 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 INFLAMMATION 4 5.00 Leukemia 4 5.00 Malignant Neoplastic Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This reveals that the expression of full length HTLV3 or just Tax3 affects the tightly regulated biosynthesis of polyamines in the cells, thereby causing disturbances in the genetic processes.

Regulation (affects) of Gene_expression (expression) of HTLV3

1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.08 Pain Relevance 0

These results indicate that the lipid metabolism pathway as well as the creatine and polyamine biosynthesis pathways are commonly deregulated after expression of HTLV3 and Tax3, indicating that the noted changes are likely due to Tax3 expression.

Regulation (deregulated) of Gene_expression (expression) of HTLV3

2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.04

General Comments

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