INT330031

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Apaf1) aging (Apaf1) Golgi apparatus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1) cytosol (Apaf1)
Anatomy Link Frequency
cleavage 2
Apaf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 21 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 18 98.44 Very High Very High Very High
Injury 5 97.84 Very High Very High Very High
Apoptosis 51 97.44 Very High Very High Very High
Death 11 96.84 Very High Very High Very High
Body Weight 28 84.32 Quite High
Hepatotoxicity 14 65.36 Quite High
Poisoning 9 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Parkinson's Disease 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As caused mitochondrial injury by increased oxidative stress and reciprocal regulation of Bcl-2, Bcl-xL/Bad, Bax, Bim in association with increased level of Apaf-1, activation of caspase 9/3, cleavage of PARP protein and ultimately led to apoptotic cell death.
Positive_regulation (increased) of Positive_regulation (activation) of Apaf-1 in cleavage associated with stress, injury, apoptosis and death
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.85 Pain Relevance 0

General Comments

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