INT330036

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.06
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Apaf1) aging (Apaf1) Golgi apparatus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1) cytosol (Apaf1)
Apaf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 18 83.84 Quite High
cytokine 3 66.72 Quite High
Inflammation 4 49.20 Quite Low
cva 5 30.04 Quite Low
Kinase C 21 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Neurobehavioral 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 58 96.44 Very High Very High Very High
Hypoxia 5 89.56 High High
Injury 13 88.68 High High
Death 13 85.16 High High
Cv Unclassified Under Development 6 83.84 Quite High
Targeted Disruption 1 82.00 Quite High
Stress 18 75.68 Quite High
Brain Hemorrhage 10 64.40 Quite High
Middle Cerebral Artery Infarction 30 53.00 Quite High
Stroke 5 50.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the cytosol, Apaf1, procaspase-9 and released cytochrome c from the mitochondria interact to form the apoptosome that drives the activation of caspase-3.
Apaf1 Binding (interact) of
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.96 Pain Relevance 0
Bax is translocated to mitochondria where it releases cytochrome c into the cytosol to interact with Apaf-1 to activate caspase-9, which in turn activates downstream caspases, such as active caspase-3 [26].
Apaf-1 Binding (interact) of
2) Confidence 0.09 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2975073 Disease Relevance 1.10 Pain Relevance 0.11

General Comments

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