INT330041

Context Info Confidence 0.29 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.63 Pain Relevance 0

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax) cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)

Bax (Rattus norvegicus)

Pain Link Frequency Relevance Heat Kinase C 42 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 102 100.00 Parkinson's Disease 4 97.32 Stress 36 91.72 Necrosis 2 47.04 Death 22 31.28 Body Weight 56 5.00 Hepatotoxicity 28 5.00 Poisoning 18 5.00 Toxicity 10 5.00 Injury 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.

Positive_regulation (induced) of Regulation (regulation) of Bax

1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.71 Pain Relevance 0

We observed that NaAsO2 induced up-regulation of pro apoptotic (active non-phospho form of Bad, Bax) and down-regulation of anti apoptotic (active non-phospho form of Bcl-2, Bcl-xL) Bcl-2 family proteins both in vivo and in vitro (Fig. 5A, 5B, 5C, 5D).

Positive_regulation (induced) of Regulation (regulation) of Bax associated with apoptosis

2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.92 Pain Relevance 0

General Comments

This test has worked.