INT330076

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.98
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
neuronal 2
brain 2
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 258 99.76 Very High Very High Very High
Hippocampus 51 86.44 High High
anesthesia 12 5.00 Very Low Very Low Very Low
Pyramidal cell 9 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Intracerebroventricular 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 165 99.76 Very High Very High Very High
Death 57 99.24 Very High Very High Very High
Cv Unclassified Under Development 90 78.40 Quite High
Apoptosis 18 70.40 Quite High
Cognitive Disorder 36 50.00 Quite Low
Stress 78 5.00 Very Low Very Low Very Low
Stroke 24 5.00 Very Low Very Low Very Low
Reperfusion Injury 18 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rac1 GTPase activation has been suggested to be critical for NADPH oxidase activation in immune cells and may have a similar role in the brain.
Regulation (critical) of Positive_regulation (activation) of GTPase in brain
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.67 Pain Relevance 0.22
We next examined the role of Rac GTPase activation in enhanced NADPH oxidase activation and O2?
Spec (examined) Regulation (role) of Spec (examined) Positive_regulation (activation) of Rac GTPase
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.48 Pain Relevance 0.24
NSC23766 treatment markedly attenuated hippocampal CA1 neuronal death following GCI, suggesting a critical role for Rac GTPase activation in delayed neuronal cell degeneration and death in the hippocampal CA1 region following GCI.


Regulation (role) of Positive_regulation (activation) of Rac GTPase in neuronal associated with ischemia and death
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.83 Pain Relevance 0.27

General Comments

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