INT33008

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 41
Total Number 42
Disease Relevance 23.85
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Dync1h1) Golgi apparatus (Dync1h1) ATPase activity (Dync1h1)
cytoskeleton (Dync1h1) cytoplasm (Dync1h1)
Anatomy Link Frequency
skin 2
fundus 2
red blood cells 2
blood 1
neurons 1
Dync1h1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.36 Very High Very High Very High
Analgesic 26 98.74 Very High Very High Very High
Central nervous system 78 98.48 Very High Very High Very High
corticosteroid 104 98.28 Very High Very High Very High
anesthesia 24 96.32 Very High Very High Very High
cva 228 96.12 Very High Very High Very High
Inflammation 85 95.08 Very High Very High Very High
tramadol 4 94.64 High High
diclofenac 8 94.56 High High
Potency 4 91.04 High High
Disease Link Frequency Relevance Heat
Infection 469 100.00 Very High Very High Very High
Intestinal Volvulus 108 99.84 Very High Very High Very High
Motor Neuron Diseases 40 99.62 Very High Very High Very High
Targeted Disruption 14 99.36 Very High Very High Very High
Sprains And Strains 40 99.28 Very High Very High Very High
Malaria 141 99.24 Very High Very High Very High
Encephalopathy 292 99.20 Very High Very High Very High
Shock 59 99.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 49 98.48 Very High Very High Very High
Urolithiasis 2 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, Chen et al. [1] have clearly shown that the ubiquitously expressed cytoplasmic dynein heavy chain is essential for the development and function of a subset of neurons in the sensory nervous system.
Gene_expression (expressed) of cytoplasmic dynein heavy chain in nervous system
1) Confidence 0.68 Published 2008 Journal Genome Biol Section Body Doc Link PMC2397497 Disease Relevance 0.14 Pain Relevance 0
Chen et al. [1] made crosses between their Swl heterozygotes and a SOD1G93A transgenic strain that models human ALS [16], and between Loa heterozytoes and the SOD1G93A strain.
Gene_expression (heterozytoes) of Loa associated with targeted disruption, sprains and strains and motor neuron diseases
2) Confidence 0.68 Published 2008 Journal Genome Biol Section Body Doc Link PMC2397497 Disease Relevance 1.04 Pain Relevance 0
The difference between the effects of the Loa and the Swl mutations when combined with the SOD1G93A transgene is intriguing, and, as Loa also causes loss of motor neurons as well as a sensory neuron defect, one interpretation of these findings is that the different dynein heavy-chain mutations are differentially affecting pathways in different types of neurons.
Gene_expression (effects) of Loa in neurons
3) Confidence 0.59 Published 2008 Journal Genome Biol Section Body Doc Link PMC2397497 Disease Relevance 0.69 Pain Relevance 0
Chen et al. [1] made crosses between their Swl heterozygotes and a SOD1G93A transgenic strain that models human ALS [16], and between Loa heterozytoes and the SOD1G93A strain.
Gene_expression (heterozygotes) of Swl associated with targeted disruption, sprains and strains and motor neuron diseases
4) Confidence 0.59 Published 2008 Journal Genome Biol Section Body Doc Link PMC2397497 Disease Relevance 1.12 Pain Relevance 0
Analgesic requirement was far less in the RPPL group as compared to the SWL group, and this difference was statistically significant (P < 0.001) [Table 3]
Gene_expression (group) of SWL associated with analgesic
5) Confidence 0.58 Published 2010 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2992658 Disease Relevance 0.46 Pain Relevance 0.24
The SWL was carried out with the Siemens Lithostar electromagnetic shockwave system, while the RPPL was carried out with the available laparoscopic instruments.
Gene_expression (carried) of SWL
6) Confidence 0.58 Published 2010 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2992658 Disease Relevance 0.26 Pain Relevance 0.20
Since its introduction in 1980, extracorporeal shockwave lithotripsy (SWL) has become the first therapeutic option in most cases of upper-tract urolithiasis, and the technique has been used for pediatric renal stones since the first report of success in 1986.
Gene_expression (introduction) of SWL in upper associated with urolithiasis
7) Confidence 0.58 Published 2008 Journal J. Endourol. Section Abstract Doc Link 18177237 Disease Relevance 0.23 Pain Relevance 0.26
Since the introduction of SWL for the removal of stones, this procedure has been optimized, and new instruments have been developed to increase utility to urologists and to improve tolerability for the patient.
Gene_expression (introduction) of SWL
8) Confidence 0.58 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684403 Disease Relevance 0.56 Pain Relevance 0.10
In the current study, we examined subjective patient satisfaction with objective outcomes in patients undergoing SWL or URS for proximal ureteral stones.
Gene_expression (undergoing) of SWL in proximal
9) Confidence 0.58 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2991578 Disease Relevance 0.11 Pain Relevance 0.05
Patients who had no breakage of the stone after 3 sessions of SWL mostly chose additional SWL, and ultimately became stone-free after 4 to 9 sessions of SWL, except for 4 patients (2.6%) who were treated with salvage URS.
Gene_expression (chose) of SWL
10) Confidence 0.58 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2991578 Disease Relevance 0.16 Pain Relevance 0.14
Of these, 50 cases had incomplete fragmentation and were termed as SWL failures.
Neg (failures) Gene_expression (failures) of SWL
11) Confidence 0.56 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684398 Disease Relevance 0.33 Pain Relevance 0.18
Later, Belgian workers in the Mayumbe District in the south-western part of the Democratic Republic of the Congo (DRC), commented on the local human Loa infections in that area being particularly liable to give rise to cases of Loa-encephalopathy after treatment with diethylcarbamazine citrate (DEC).
Gene_expression (infections) of Loa associated with encephalopathy and infection
12) Confidence 0.53 Published 2004 Journal Filaria J Section Body Doc Link PMC514527 Disease Relevance 0.58 Pain Relevance 0
Urinary infections were treated prior to the SWL session.
Gene_expression (session) of SWL associated with infection
13) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2972613 Disease Relevance 0.27 Pain Relevance 0.30
Indeed, Wolbachia have also been found in Loa loa, but in such low quantity that they are unlikely to contribute to the reactions developed by loiasis patients [71].
Gene_expression (found) of Loa associated with loiasis
14) Confidence 0.48 Published 2003 Journal Filaria J Section Body Doc Link PMC2147657 Disease Relevance 0.81 Pain Relevance 0.17
At that time, 52 of the 112 patients were co-infected with both Loa loa and Onchocerca volvulus, but the microfilarial counts of the latter parasite were very low: only 13 patients had 10 mf per skin snip or more, and the median O. volvulus microfilarial load in the infected individuals was 3 mf per skin snip.


Gene_expression (infected) of Loa in skin associated with intestinal volvulus
15) Confidence 0.48 Published 2003 Journal Filaria J Section Body Doc Link PMC2147657 Disease Relevance 0.51 Pain Relevance 0.06
Though the result on the red blood cells might mean that the CSF was contaminated with blood, and thus microfilariae, from a vessel injured during the tap, the presence of these Loa loa microfilariae suggested that the renal and neurological conditions of the patient might correspond to complications of a Loa loa infection.
Gene_expression (infection) of Loa in red blood cells associated with infection
16) Confidence 0.43 Published 2006 Journal Filaria J Section Body Doc Link PMC1471781 Disease Relevance 0.76 Pain Relevance 0.07
This is sometimes due to the cost of the required examinations but we do think that two of them should be made on patients who are infected with Loa loa and who present an encephalopathy: an examination of the fundus, to see whether there are typical retinal haemorrhages, and a direct examination of centrifuged sample of CSF.
Gene_expression (infected) of Loa in fundus associated with encephalopathy, cva and retina disease
17) Confidence 0.43 Published 2006 Journal Filaria J Section Body Doc Link PMC1471781 Disease Relevance 1.10 Pain Relevance 0.10
In the absence of histological results, it is difficult to affirm that the renal and neurological troubles developed by our patient were indeed caused by his high Loa loa infection.
Gene_expression (infection) of Loa associated with infection
18) Confidence 0.43 Published 2006 Journal Filaria J Section Body Doc Link PMC1471781 Disease Relevance 0.43 Pain Relevance 0.06
As Plasmodium infection is also very frequent in those areas endemic for Loa loa, these observations may be purely coincidental.
Gene_expression (endemic) of Loa associated with malaria
19) Confidence 0.43 Published 2006 Journal Filaria J Section Body Doc Link PMC1471781 Disease Relevance 0.82 Pain Relevance 0
Two options were considered to treat the Loa loa infection: diethylcarbamazine (DEC) associated with corticosteroids, and a treatment with Vofil – a speciality made of medicinal plants, manufactured and marketed in DRC – in association with astemisol, an antihistaminic.
Gene_expression (infection) of Loa associated with corticosteroid and infection
20) Confidence 0.43 Published 2006 Journal Filaria J Section Body Doc Link PMC1471781 Disease Relevance 0.70 Pain Relevance 0.10

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