INT330088

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb)
plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Cybb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 4 87.52 High High
Hippocampus 34 75.44 Quite High
ischemia 172 73.16 Quite High
anesthesia 8 65.36 Quite High
cerebral cortex 4 63.76 Quite High
Pyramidal cell 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 52 83.08 Quite High
Cv Unclassified Under Development 60 73.16 Quite High
Stroke 16 72.80 Quite High
Targeted Disruption 4 71.08 Quite High
Apoptosis 12 69.60 Quite High
Death 38 67.56 Quite High
Injury 6 64.68 Quite High
Cv General 4 Under Development 110 50.00 Quite Low
Cognitive Disorder 24 50.00 Quite Low
Reperfusion Injury 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once active, Rac-GTP associates with the membrane and interacts with the tetratricopeptide repeat (TPR) site on p67phox subunit [13] and with membrane bound NOX2, resulting in NADPH oxidase complex activation [14], [15].
NOX2 Binding (bound) of
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.56 Pain Relevance 0.13
To investigate the role of NOX2 NADPH oxidase, we utilized a specific competitive NOX2 inhibitor, gp91ds-tat, which is a 9 amino acid peptide sequence of the p47Phox docking site on NOX2 and prevents p47phox from forming a complex with NOX2 [22].
NOX2 Binding (complex) of
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.14 Pain Relevance 0.18

General Comments

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