INT33009

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Context Info
Confidence 0.31
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.69
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
4T1 1
Cdk2ap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.68 Very High Very High Very High
Potency 1 91.04 High High
Intracerebroventricular 1 81.80 Quite High
opioid receptor 1 72.24 Quite High
cytokine 14 54.04 Quite High
Inflammation 35 39.00 Quite Low
chemokine 3 35.52 Quite Low
metalloproteinase 3 26.68 Quite Low
endometriosis 24 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 690 99.64 Very High Very High Very High
Colon Cancer 392 99.50 Very High Very High Very High
Targeted Disruption 34 99.46 Very High Very High Very High
Apoptosis 7 80.20 Quite High
Overactive Bladder 1 79.48 Quite High
Gastric Motility Disorder 5 77.96 Quite High
Hypoxia 2 74.48 Quite High
Microsatellite Instability 164 66.56 Quite High
Malignant Neoplastic Disease 20 56.48 Quite High
Stress 3 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Gene_expression (levels) of CDK2ap1 in 4T1
1) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.19 Pain Relevance 0.03
Down-regulation of tight junction proteins was already observed at P12, whereas enhanced water loss was only seen after P18.
Gene_expression (seen) of P12
2) Confidence 0.26 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.05 Pain Relevance 0
Normal adjacent mucosa from the Mlh1 knockout mouse demonstrated normal CDK2-AP1 expression.
Gene_expression (expression) of CDK2-AP1 associated with targeted disruption
3) Confidence 0.02 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 1.67 Pain Relevance 0
CDK2-AP1 expression in the MSI mouse tumors and adjacent normal mucosa was assessed using RT-PCR and Western blot analysis.
Gene_expression (expression) of CDK2-AP1 associated with cancer
4) Confidence 0.02 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 1.39 Pain Relevance 0
In contrast, tumors harvested from a control transgenic APC1638N mouse demonstrated the MSS phenotype and normal CDK2-AP1 expression as measured by mRNA and protein analysis.
Gene_expression (expression) of CDK2-AP1 associated with targeted disruption and cancer
5) Confidence 0.02 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 1.62 Pain Relevance 0
A human CRC tissue array containing 43 microsatellite stable (MSS) and 7 MSI CRC tumors was analyzed for CDK2-AP1 expression using standard immunohistochemistry techniques.


Spec (analyzed) Gene_expression (expression) of CDK2-AP1 associated with cancer and colon cancer
6) Confidence 0.02 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 1.60 Pain Relevance 0
The total formation of BAM22P, BAM12P, [Met5]enkephalin and all other peptide fragments during a 40 min incubation period accounted for only 8% of the total peptide E added to the homogenates.
Gene_expression (formation) of BAM12P associated with enkephalin
7) Confidence 0.02 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990950 Disease Relevance 0.16 Pain Relevance 0.31

General Comments

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