INT330097

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.47
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
neural 2
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 258 99.98 Very High Very High Very High
Hippocampus 51 86.08 High High
Pyramidal cell 9 51.68 Quite High
cerebral cortex 6 35.60 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Intracerebroventricular 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 165 99.98 Very High Very High Very High
Cv Unclassified Under Development 90 99.56 Very High Very High Very High
Stress 78 98.76 Very High Very High Very High
Pressure And Volume Under Development 3 85.84 High High
Brain Hemorrhage 3 85.28 High High
Cognitive Disorder 36 79.12 Quite High
Reperfusion Injury 18 71.16 Quite High
Death 57 42.16 Quite Low
Targeted Disruption 6 39.84 Quite Low
Apoptosis 18 36.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is postulated that regulation of Tiam1 and Trio following cerebral ischemia contributes to the enhanced Rac1 GTPase activation following ischemia/reperfusion.
Positive_regulation (contributes) of Positive_regulation (activation) of Rac1 associated with cv general 4 under development and ischemia
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.71 Pain Relevance 0.27
Thus, it is postulated that regulation of Tiam1 and Trio following cerebral ischemia contributes to the enhanced Rac1 GTPase activation following ischemia/reperfusion.
Positive_regulation (enhanced) of Positive_regulation (activation) of Rac1 associated with cv general 4 under development and ischemia
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.71 Pain Relevance 0.27
These findings, coupled with the results of the current study, support a critical role for Rac1 GTPase activation in the induction of oxidative stress in both neural and non-neural tissues.
Positive_regulation (role) of Positive_regulation (activation) of Rac1 in neural associated with stress
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.04 Pain Relevance 0.31

General Comments

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