INT330223

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0

nucleoplasm (Prkaa2) peptidase activity (Tmprss5) nucleus (Prkaa2) plasma membrane (Tmprss5) protein binding, bridging (Prkaa2) protein complex (Prkaa2)

Tmprss5 (Rattus norvegicus) Prkaa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat imagery 2 5.00 cytokine 1 5.00 Kinase C 1 5.00 qutenza 1 5.00

Disease Link Frequency Relevance Heat Stress 22 94.60 Cancer 1 86.56 Shock 1 22.96 Hypoxia 1 12.00 Parkinson's Disease 2 5.00 Immunization 1 5.00 Diabetes Mellitus 1 5.00 Targeted Disruption 1 5.00 Hypertrophy 1 5.00 Hepatocellular Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AMP binding stimulates AMPK by two mechanisms: (1) allosteric activation of phosphorylated AMPK, and (2) inhibition of dephosphorylation of Thr-172 by protein phosphatases (Davies et al., 1995; Suter et al., 2006; Sanders et al., 2007b).

AMP Binding (binding) of Positive_regulation (stimulates) of AMPK

1) Confidence 0.01 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.