INT330371

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
TLR3 (Homo sapiens)
Ifx (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 84 70.68 Quite High
agonist 2 58.52 Quite High
Central nervous system 42 41.08 Quite Low
imagery 54 5.00 Very Low Very Low Very Low
Pain 32 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
positron emission tomography 24 5.00 Very Low Very Low Very Low
Nerve growth factor 20 5.00 Very Low Very Low Very Low
Peripheral nervous system 16 5.00 Very Low Very Low Very Low
Multiple sclerosis 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 734 100.00 Very High Very High Very High
Meningitis 2 97.64 Very High Very High Very High
Infection 134 84.32 Quite High
Viral Meningitis 8 74.76 Quite High
Virus Diseases 4 41.64 Quite Low
Death 12 35.96 Quite Low
Apoptosis 60 34.24 Quite Low
Cancer 404 5.00 Very Low Very Low Very Low
Disease 68 5.00 Very Low Very Low Very Low
Pain 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR3 seems to be the dominant TLR involved in recognition of HSV-1, and patients with dominant-negative TLR3 mutations were recently found to be highly susceptible to herpes simplex encephalitis (HSE) [312].
TLR3 Binding (recognition) of HSV-1 associated with meningitis and cold sores
1) Confidence 0.17 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.56 Pain Relevance 0.10
TLR3 seems to be the dominant TLR involved in recognition of HSV-1, and patients with dominant-negative TLR3 mutations were recently found to be highly susceptible to herpes simplex encephalitis (HSE) [312].
TLR3 Binding (recognition) of HSV-1 associated with meningitis and cold sores
2) Confidence 0.15 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

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