INT330414

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.58
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Aldh2) oxidoreductase activity (Aldh2)
Anatomy Link Frequency
heart 8
myocardium 2
cardiovascular system 2
Aldh2 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 90 99.50 Very High Very High Very High
Kinase C 16 96.64 Very High Very High Very High
fibrosis 10 92.88 High High
tolerance 167 89.80 High High
Potency 15 31.76 Quite Low
Angina 52 5.00 Very Low Very Low Very Low
Dopamine 20 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Serotonin 11 5.00 Very Low Very Low Very Low
gABA 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 40 99.96 Very High Very High Very High
Alcohol Addiction 30 99.96 Very High Very High Very High
Targeted Disruption 103 99.88 Very High Very High Very High
Apoptosis 40 99.24 Very High Very High Very High
Insulin Resistance 10 99.24 Very High Very High Very High
Stress 258 97.08 Very High Very High Very High
Toxicity 90 97.02 Very High Very High Very High
Fibrosis 10 92.88 High High
Diabetes Mellitus 89 85.24 High High
Kyphosis 10 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, overexpression of ALDH2 was associated with a suppression of phosphatase activity which leads to enhanced Akt and AMP-activated protein kinase activities and regulation of their downstream targets Foxo3 transcription factor and caspase-3.87,88 Thus, ALDH2 appears critical in protecting the heart from aldehyde toxicity and is able to elicit signalling events that can protect against myocardial damages caused by acute ethanol toxicity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ALDH2 in heart associated with toxicity
1) Confidence 0.69 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.58 Pain Relevance 0.03
Overexpression of ALDH2 wild-type enzymes appeared to confer multiple beneficial effects to the heart tissue and cardiac functions in another transgenic mice model.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ALDH2 in heart associated with targeted disruption
2) Confidence 0.69 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.52 Pain Relevance 0.03
Control mice placed on a 4% alcohol liquid diet for 14-week developed cardiac hypertrophy and contractile defects, whereas mice overexpressing ALDH2 exhibited a significant attenuation of cardiac hypertrophy and contractile dysfunction.34 These improvements were attributed to better calcium handling, reduction in myocardial fibrosis, reduction in protein carbonyl formation, and reduction in apoptosis, likely through a molecular mechanism associated with phosphorylation of apoptosis-stimulated kinase, glycogen synthase kinase-3?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ALDH2 associated with fibrosis, apoptosis, coronary heart disease and alcohol
3) Confidence 0.69 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 1.06 Pain Relevance 0.20
Ma et al.87 explored the effect of ALDH2 overexpression on acute ethanol-induced myocardium damage.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ALDH2 in myocardium
4) Confidence 0.69 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.46 Pain Relevance 0.03
Acetaldehyde toxicity also results in an exacerbated cardiac hypertrophy and contractile defect.89,90 In models of chronic alcohol ingestion, mimicking human alcoholism, overexpression of the ALDH2 enzyme dramatically reduced the complications of the cardiovascular system.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ALDH2 in cardiovascular system associated with alcohol addiction, toxicity, coronary heart disease and alcohol
5) Confidence 0.69 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.89 Pain Relevance 0.13
Related to alcohol-induced cardiomyopathy, overexpression of ALDH2 can also overcome insulin resistance in the heart of chronically alcohol-fed mice via an improvement of insulin signalling.91 This ALDH2-mediated protection mechanism also extends to the brain as apoptosis and cerebral damages were ablated in ALDH2 overexpressing mice after 12 weeks of continuous ethanol ingestion.92
Positive_regulation (overexpression) of Gene_expression (overexpression) of ALDH2 in heart associated with apoptosis, insulin resistance, coronary heart disease and alcohol
6) Confidence 0.50 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 1.17 Pain Relevance 0.22
Another approach to studying the potential consequences of E487K mutation represented in the ALDH2*2 carrying East Asians is the use of transgenic mice overexpressing ALDH2*2.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ALDH2 associated with targeted disruption
7) Confidence 0.50 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 1.03 Pain Relevance 0.14
Related to alcohol-induced cardiomyopathy, overexpression of ALDH2 can also overcome insulin resistance in the heart of chronically alcohol-fed mice via an improvement of insulin signalling.91 This ALDH2-mediated protection mechanism also extends to the brain as apoptosis and cerebral damages were ablated in ALDH2 overexpressing mice after 12 weeks of continuous ethanol ingestion.92
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ALDH2 in heart associated with apoptosis, insulin resistance, coronary heart disease and alcohol
8) Confidence 0.50 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 1.11 Pain Relevance 0.20
It should be noted that since ALDHs are tetramers, it is possible that overexpression of ALDH2*2 monomer inactivates not only the wild-type ALDH2, but may also form heterotetramers and inactive other ALDH isozymes (e.g. heterotetramer formation between ALDH2 and another highly homologous ALDH1B1).81,94 Since ALDH2*2 levels were eight-fold higher than that of the endogenous ALDH2 wild-type protein in the mitochondria, ALDH2*2 may therefore have pleiotropic effects.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ALDH2
9) Confidence 0.46 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.64 Pain Relevance 0.04
These negative outcomes were much reduced in mice expressing four-fold higher levels of ALDH2.
Positive_regulation (levels) of Gene_expression (expressing) of ALDH2
10) Confidence 0.46 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.54 Pain Relevance 0.03
Recently, Ma et al. have demonstrated that ALDH-2 knockout aggravated, and ALDH-2 overexpression improved, ischemic damage in response to experimental MI [113].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ALDH-2 associated with targeted disruption
11) Confidence 0.17 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014692 Disease Relevance 0.59 Pain Relevance 0.05

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