INT330424

Context Info Confidence 0.22 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0.04

mitochondrion (Aldh2, Aldh1b1) oxidoreductase activity (Aldh2, Aldh1b1) nucleus (Aldh1b1)

Aldh2 (Mus musculus) Aldh1b1 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 11 83.24 alcohol 9 37.56 fibrosis 1 21.96 Angina 5 5.00 agonist 2 5.00 Dopamine 2 5.00 noradrenaline 1 5.00 addiction 1 5.00 gABA 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Stress 23 90.52 Targeted Disruption 10 81.72 Kyphosis 1 75.56 Osteoporosis 1 75.16 Apoptosis 4 42.88 Insulin Resistance 1 36.12 Coronary Heart Disease 4 33.64 Fibrosis 1 21.96 Cv Unclassified Under Development 15 5.00 Myocardial Infarction 11 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It should be noted that since ALDHs are tetramers, it is possible that overexpression of ALDH2*2 monomer inactivates not only the wild-type ALDH2, but may also form heterotetramers and inactive other ALDH isozymes (e.g. heterotetramer formation between ALDH2 and another highly homologous ALDH1B1).81,94 Since ALDH2*2 levels were eight-fold higher than that of the endogenous ALDH2 wild-type protein in the mitochondria, ALDH2*2 may therefore have pleiotropic effects.

ALDH2 Binding (formation) of ALDH1B1

1) Confidence 0.22 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.65 Pain Relevance 0.04

General Comments

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