INT330425

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Aldh2) oxidoreductase activity (Aldh2) nucleolus (Zmat3)
Aldh2 (Mus musculus)
Zmat3 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 11 89.80 High High
alcohol 9 44.12 Quite Low
fibrosis 1 28.52 Quite Low
Angina 5 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
noradrenaline 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 23 97.08 Very High Very High Very High
Targeted Disruption 10 88.28 High High
Kyphosis 1 82.12 Quite High
Osteoporosis 1 81.72 Quite High
Apoptosis 4 49.44 Quite Low
Insulin Resistance 1 42.68 Quite Low
Coronary Heart Disease 4 40.20 Quite Low
Fibrosis 1 28.52 Quite Low
Alcohol Addiction 3 10.92 Low Low
Toxicity 9 5.04 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It should be noted that since ALDHs are tetramers, it is possible that overexpression of ALDH2*2 monomer inactivates not only the wild-type ALDH2, but may also form heterotetramers and inactive other ALDH isozymes (e.g. heterotetramer formation between ALDH2 and another highly homologous ALDH1B1).81,94 Since ALDH2*2 levels were eight-fold higher than that of the endogenous ALDH2 wild-type protein in the mitochondria, ALDH2*2 may therefore have pleiotropic effects.
Gene_expression (overexpression) of ALDH2 Negative_regulation (inactivates) of wild-type
1) Confidence 0.00 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.64 Pain Relevance 0.04

General Comments

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