INT330428

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0

mitochondrion (Aldh2) signal transduction (Gnat3) oxidoreductase activity (Aldh2) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Gnat3 (Mus musculus) Aldh2 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 11 5.00 alcohol 9 5.00 Angina 5 5.00 agonist 2 5.00 Dopamine 2 5.00 fibrosis 1 5.00 noradrenaline 1 5.00 addiction 1 5.00 gABA 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Stress 23 97.04 Heart Disease 5 71.28 Cv Unclassified Under Development 15 56.48 Toxicity 9 41.04 Myocardial Infarction 11 40.80 Ischemic Heart Disease 3 36.48 Targeted Disruption 10 5.00 Cardiovascular Disease 7 5.00 Cv General 3 Under Development 5 5.00 Coronary Heart Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alda-1 increases ALDH2 activity by about two-folds, blocks ALDH2 inactivation by both aldehydes and GTN, and thus increases the cell's natural ability to protect from oxidative stress, leading to 60% reduction from cardiac damage in an animal model of AMI.

GTN Negative_regulation (inactivation) of ALDH2 associated with stress

1) Confidence 0.11 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.44 Pain Relevance 0

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