INT330429

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gnat3, Gnat3) GTPase activity (Gnat3, Gnat3) cytoplasm (Gnat3, Gnat3)
signal transducer activity (Gnat3, Gnat3) mitochondrion (Aldh2) oxidoreductase activity (Aldh2)
Gnat3 (Mus musculus)
Gnat3 (Mus musculus)
Aldh2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 11 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
noradrenaline 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 23 97.04 Very High Very High Very High
Heart Disease 5 71.56 Quite High
Cv Unclassified Under Development 15 56.48 Quite High
Toxicity 9 41.32 Quite Low
Myocardial Infarction 11 40.80 Quite Low
Ischemic Heart Disease 3 36.76 Quite Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Cardiovascular Disease 7 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 5 5.00 Very Low Very Low Very Low
Coronary Heart Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alda-1 increases ALDH2 activity by about two-folds, blocks ALDH2 inactivation by both aldehydes and GTN, and thus increases the cell's natural ability to protect from oxidative stress, leading to 60% reduction from cardiac damage in an animal model of AMI.
GTN Negative_regulation (blocks) of GTN Negative_regulation (inactivation) of ALDH2 associated with stress
1) Confidence 0.03 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.44 Pain Relevance 0

General Comments

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