INT330525

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DICER1) intracellular (DICER1) helicase activity (DICER1)
cytoplasm (DICER1)
Anatomy Link Frequency
B cell 1
T cell 1
DICER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 55 96.80 Very High Very High Very High
Multiple sclerosis 317 91.84 High High
cytokine 54 59.44 Quite High
Inflammatory stimuli 2 36.72 Quite Low
Inflammation 61 5.00 Very Low Very Low Very Low
Central nervous system 54 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 61 96.80 Very High Very High Very High
Apoptosis 24 95.68 Very High Very High Very High
Demyelinating Disease 351 91.84 High High
Disease 147 79.68 Quite High
Death 25 76.16 Quite High
Benign Prostatic Hypertrophy 1 69.24 Quite High
Sarcoma 2 68.32 Quite High
Cytomegalovirus Infection 2 66.68 Quite High
Reprotox - General 1 4 66.32 Quite High
Cancer 18 56.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One interpretation of these data is that antigen specific T cell clones increase their survival following DcR1 upregulation.
Positive_regulation (upregulation) of DcR1 in T cell
1) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.98 Pain Relevance 0.31
Interestingly, the changes observed by gene expression profiling of Dicer-deficient B cell precursors are generally similar to those observed in B cells lacking the miR-17–92 family.
Positive_regulation (profiling) of Dicer in B cell
2) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0
Two recent studies showed that differentiation and homeostasis of iNKT cells require Dicer in a cell-autonomous fashion [146, 147].
Positive_regulation (require) of Dicer
3) Confidence 0.05 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

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