INT330526

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.34
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DICER1) intracellular (DICER1) helicase activity (DICER1)
cytoplasm (DICER1)
Anatomy Link Frequency
T cells 4
DICER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 220 99.64 Very High Very High Very High
Multiple sclerosis 162 97.64 Very High Very High Very High
cytokine 27 94.20 High High
Inflammation 48 86.40 High High
rheumatoid arthritis 18 32.72 Quite Low
Central nervous system 27 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 230 99.64 Very High Very High Very High
Demyelinating Disease 179 97.64 Very High Very High Very High
Disease 112 94.88 High High
Death 51 87.68 High High
Apoptosis 47 86.88 High High
INFLAMMATION 59 86.40 High High
Benign Prostatic Hypertrophy 4 84.44 Quite High
Reprotox - General 1 16 81.52 Quite High
Repression 9 64.16 Quite High
Systemic Lupus Erythematosus 15 56.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case increased DcR1 expression (about 66 fold) was the most marked.
Positive_regulation (increased) of Gene_expression (expression) of DcR1
1) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.57 Pain Relevance 0.18
These data show a 35-fold increase in DcR1 expression with a 10-15-fold increase in the other markers.
Positive_regulation (increase) of Gene_expression (expression) of DcR1
2) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.93 Pain Relevance 0.36
Recently, elevated expression of DcR1 was detected in antigen specific T cells of patients with multiple sclerosis (MS) [22].
Positive_regulation (elevated) of Gene_expression (expression) of DcR1 in T cells associated with multiple sclerosis
3) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.82 Pain Relevance 0.24
The most dramatic change in the amount of TRAIL/TRAIL receptor present on peripheral blood lymphocytes of RA patients was the increased DcR1 expression seen in both CD4+ and CD8+ T cells.
Positive_regulation (increased) of Gene_expression (expression) of DcR1 in T cells associated with arthritis
4) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.87 Pain Relevance 0.26
has been shown to inhibit Dicer expression, which results in decrease of pre-miRNA processing, whereas IFN-?
Positive_regulation (results) of Gene_expression (expression) of Dicer
5) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.15 Pain Relevance 0.14

General Comments

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