INT33053

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.74
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cox6c) biological_process (Cox6c)
Anatomy Link Frequency
cerebral cortex 1
cortex 1
hippocampus 1
Cox6c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 5 99.42 Very High Very High Very High
cerebral cortex 3 99.32 Very High Very High Very High
Hippocampus 3 98.52 Very High Very High Very High
alcohol 9 98.28 Very High Very High Very High
cva 19 97.14 Very High Very High Very High
anesthesia 5 95.88 Very High Very High Very High
Central nervous system 15 94.72 High High
depression 4 92.00 High High
Pain 10 89.28 High High
hyperexcitability 6 84.64 Quite High
Disease Link Frequency Relevance Heat
Stress 19 99.02 Very High Very High Very High
Cardiomegaly 3 99.00 Very High Very High Very High
Mitochondrial Disorders 5 98.56 Very High Very High Very High
Cv General 4 Under Development 18 97.14 Very High Very High Very High
Death 4 94.48 High High
Depression 4 92.00 High High
Nerve Compression Syndromes 45 88.32 High High
Obesity 5 87.28 High High
Ganglion Cysts 72 80.88 Quite High
Pain 11 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of 20% ethyl alcohol instead of drinking water during EPS partially prevented vegetative disturbances and activation of hippocampal cytochrome oxidase and fully prevented the heart hypertrophy and activation of the enzyme in the cortex.
Positive_regulation (activation) of cytochrome oxidase in cortex associated with cardiomegaly, stress and alcohol
1) Confidence 0.69 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2992633 Disease Relevance 0.69 Pain Relevance 0.37
The increase of the heart weight and activation of cytochrome oxidase activity in the cerebral cortex and hippocampus of rats exposed to EPS were also demonstrated.
Positive_regulation (activation) of cytochrome oxidase in cerebral cortex associated with stress, hippocampus and cerebral cortex
2) Confidence 0.69 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2992633 Disease Relevance 0.66 Pain Relevance 0.38
Following a subarachnoid hemorrhage (SAH), adult rats exhibit dynamic regional changes in cerebral glucose metabolism characterized by an increase in metabolic rates and a subsequent upregulation of cytochrome oxidase (CO).
Positive_regulation (upregulation) of cytochrome oxidase associated with cv general 4 under development and cva
3) Confidence 0.30 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 11990351 Disease Relevance 0.35 Pain Relevance 0.26
VB was sharply demarcated in sections reacted for cytochrome oxidase (CO) activity.
Positive_regulation (reacted) of cytochrome oxidase
4) Confidence 0.26 Published 1988 Journal J. Neurophysiol. Section Abstract Doc Link 3193152 Disease Relevance 0 Pain Relevance 0.10
The increase of the heart weight and activation of cytochrome oxidase activity in the cerebral cortex and hippocampus of rats exposed to EPS were also demonstrated.
Positive_regulation (activation) of cytochrome oxidase in hippocampus associated with stress, hippocampus and cerebral cortex
5) Confidence 0.24 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2992633 Disease Relevance 0.66 Pain Relevance 0.38
Cytochrome oxidase also increased from 1% to 9% above sham levels, peaking on day 3.
Positive_regulation (increased) of Cytochrome oxidase
6) Confidence 0.20 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 11990351 Disease Relevance 0.66 Pain Relevance 0.41
Loss of peripheral trophic factors and decreased depolarizing activity (action potential discharge) were proposed to contribute to decreased cytochrome oxidase activity in these cells [57].
Positive_regulation (contribute) of cytochrome oxidase associated with action potential
7) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.41 Pain Relevance 0.24
Because mitochondrial diseases in mammals are often accompanied by elevated lactic acid, reduced ATP, increased cytochrome oxidase (COX) activity, and the morphological alteration of mitochondria [13]–[15], we measured lactic acid levels and ATP contents in the CNS and performed morphological analyses of the CNS of dmy/dmy rats.
Positive_regulation (increased) of cytochrome oxidase associated with mitochondrial disorders and central nervous system
8) Confidence 0.04 Published 2011 Journal PLoS Genetics Section Body Doc Link PMC3017111 Disease Relevance 0.19 Pain Relevance 0.09
The electrons then flow via coenzyme Q (ubiquinone) to complex III, and are then transported via cytochrome C to reach complex IV (cytochrome oxidase).
Positive_regulation (reach) of cytochrome oxidase
9) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1751057 Disease Relevance 0.11 Pain Relevance 0

General Comments

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