INT33057

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 4.05
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dsp) protein binding, bridging (Dsp)
Anatomy Link Frequency
scallops 1
filament 1
plaque 1
Dsp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 11 100.00 Very High Very High Very High
Catecholamine 1 100.00 Very High Very High Very High
opioid receptor 2 99.76 Very High Very High Very High
narcan 12 99.40 Very High Very High Very High
antagonist 20 97.64 Very High Very High Very High
noradrenaline 9 96.12 Very High Very High Very High
Pain 9 95.56 Very High Very High Very High
Desipramine 3 94.52 High High
cocaine 1 90.84 High High
Opioid 1 89.84 High High
Disease Link Frequency Relevance Heat
Neuropathy 26 100.00 Very High Very High Very High
Shellfish Poisoning 10 100.00 Very High Very High Very High
Poisoning 9 100.00 Very High Very High Very High
Death 2 98.08 Very High Very High Very High
Syndrome 14 97.20 Very High Very High Very High
Dysesthesia 1 96.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 25 95.92 Very High Very High Very High
Pain 8 95.56 Very High Very High Very High
Mycobacterial Infection 4 94.60 High High
Myocardial Infarction 12 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stavudine use was significantly associated with DSP.
DSP Binding (associated) of associated with neuropathy
1) Confidence 0.36 Published 2010 Journal Muscle Nerve Section Abstract Doc Link 20229576 Disease Relevance 1.84 Pain Relevance 0.14
In view of our previous observations that DSP4 can interact with opioid receptors, we attempted to block its inhibitory effect on PMSG and EB/P stimulations.
DSP4 Binding (interact) of associated with opioid receptor
2) Confidence 0.35 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3382969 Disease Relevance 0 Pain Relevance 0.27
CONCLUSIONS/INTERPRETATION: This pilot study shows, for the first time, that HF can ameliorate the discomfort and pain associated with DSP, and suggests that HF is more effective than TENS.
DSP Binding (associated) of
3) Confidence 0.31 Published 2005 Journal Diabetologia Section Body Doc Link 15830180 Disease Relevance 0 Pain Relevance 0
Although it has been reported that DSP4 binds the opiate receptor, intrabursal co-administration of the antagonist naloxone was ineffective in altering ovulatory suppression.
DSP4 Binding (binds) of associated with antagonist, narcan and opiate
4) Confidence 0.30 Published 1996 Journal J. Reprod. Fertil. Section Abstract Doc Link 8699411 Disease Relevance 0 Pain Relevance 0.52
Thus, DSP4 is not the drug of choice for experiments designed to probe catecholamine-opiate interactions in the control of LH release.
DSP4 Binding (interactions) of associated with catecholamine and opiate
5) Confidence 0.28 Published 1985 Journal Exp Brain Res Section Abstract Doc Link 2993014 Disease Relevance 0 Pain Relevance 0.56
The noradrenergic neurotoxins DSP4 and xylamine bind to opiate receptors.
DSP4 Binding (bind) of associated with narcan and opiate
6) Confidence 0.18 Published 1985 Journal Brain Res. Bull. Section Title Doc Link 2992718 Disease Relevance 0 Pain Relevance 0.83
Therefore, desmoplakin is required for the docking and integration of the intermediate filament system with the desmosomal cadherins, either through direct physical interaction or as part of a complex through interaction with the armadillo proteins, PG and PKP2.
desmoplakin Binding (interaction) of in filament
7) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0
These studies indicate that the functional upregulation of CCR2 and CXCR4 signaling systems following a combination of gp120 and an NRTI are likely to be of central importance to associated DSP and may serve as potential therapeutic targets for treatment of this syndrome.



DSP Spec (likely) Binding (associated) of associated with neuropathy and syndrome
8) Confidence 0.08 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2734548 Disease Relevance 0.70 Pain Relevance 0.26
The recruitment of PKP2 to the new intercalated disk may be required for the next phase of desmosomal assembly, namely, the linkage of the transmembrane complex with the intermediate filaments of the cellular cytoskeleton through the desmosomal plaque protein, desmoplakin.
desmoplakin Binding (linkage) of in plaque
9) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0
I therefore advocate early intubation with DSP in patients developing a reduced LOC

Controversies in cardiopulmonary resuscitation

DSP Binding (intubation) of associated with poisoning
10) Confidence 0.05 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2734532 Disease Relevance 0.70 Pain Relevance 0
DSP has been associated with the consumption of mussels, scallops, or clams tainted with OA and its analogs or derivatives.
DSP Binding (associated) of in scallops associated with shellfish poisoning
11) Confidence 0.04 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525486 Disease Relevance 0.81 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox