INT3306

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Context Info
Confidence 0.12
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.24
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Anatomy Link Frequency
leukocytes 4
lung 2
granulocyte 1
phagocyte 1
PMN 1
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 127 99.98 Very High Very High Very High
metalloproteinase 459 99.96 Very High Very High Very High
Inflammatory stimuli 4 99.96 Very High Very High Very High
lidocaine 411 99.72 Very High Very High Very High
Inflammation 463 98.76 Very High Very High Very High
dexamethasone 18 96.52 Very High Very High Very High
Inflammatory response 47 90.16 High High
cINOD 4 75.00 Quite High
Arthritis 1 69.20 Quite High
Analgesic 4 65.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 522 99.78 Very High Very High Very High
Urological Neuroanatomy 10 99.14 Very High Very High Very High
Coronary Artery Disease 4 98.36 Very High Very High Very High
Bacterial Infection 25 96.68 Very High Very High Very High
Lung Injury 31 92.88 High High
Peritonitis 24 89.76 High High
Pneumonia 145 88.72 High High
Injury 53 88.68 High High
Sepsis 54 88.52 High High
Infection 44 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that Y-9213 may stabilize membranes of erythrocytes and lysosomes and inhibit phagocytic secretion of lysosomal constitutents from PMN leukocytes.
Localization (secretion) of PMN in leukocytes
1) Confidence 0.12 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 702946 Disease Relevance 0.07 Pain Relevance 0.19
The release of enzymes from the PMN leukocyte lysosomes preincubated at 37 degrees C for 15 min was strongly inhibited by dexamethasone, prednisolone and hydrocortisone (1--100 micrometer), but not by Y-9213, phenylbutazone and indomethacin (100 micrometer).
Localization (release) of PMN in leukocyte associated with dexamethasone
2) Confidence 0.12 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 702946 Disease Relevance 0.27 Pain Relevance 0.29
Y-9213 (1--100 micrometer) inhibited considerably the release of enzymes from intact lysosomes of rabbit polymorphonuclear (PMN) leukocytes.
Localization (release) of PMN in leukocytes
3) Confidence 0.12 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 702946 Disease Relevance 0.28 Pain Relevance 0.29
Y-9213 (0.1--10 micrometer) also inhibited significantly the phagocytic secretion of lysosomal enzymes from PMN leukocytes without affecting phagocytosis of the particles.
Localization (secretion) of PMN in leukocytes
4) Confidence 0.12 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 702946 Disease Relevance 0.23 Pain Relevance 0.23
In addition, the NEP activity was higher in the LPS-treated mice, in which the recruitment of PMN into the air-space was increased.
Localization (recruitment) of PMN
5) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.93 Pain Relevance 0.16
Both S100A8 and S100A9 are known to be abundant cytosolic proteins in human PMN that can be secreted and exhibit potent actions in inflammatory cell recruitment [20].
Localization (secreted) of PMN associated with inflammation
6) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.74 Pain Relevance 0.63
The time course of PMN infiltration followed a similar trend, peaking (17.5±2.5×106 PMN) at 12 h after zymosan challenge (Fig. 1A).
Localization (infiltration) of PMN
7) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.52 Pain Relevance 0.61
These results suggested that lidocaine might hamper PMN clearance during the normal spontaneous resolution phase of acute inflammation.
Localization (clearance) of PMN associated with inflammation and lidocaine
8) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.19 Pain Relevance 0.67
Two time intervals were selected for analysis: one at 4 h within the early inflammatory phase, and the second at 24 h within the resolution phase, since lidocaine gave the most dramatic impact on PMN infiltration at these two time points (see Fig. 1A).
Localization (infiltration) of PMN associated with inflammation and lidocaine
9) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.40 Pain Relevance 0.69
Halbertsma states that the biotrauma associated with mechanical ventilation causes cytokine release (IL-6, IL-8, TNF-alpha) with consecutive PMN recruitment to the lung [13].
Localization (release) of PMN in lung associated with cytokine
10) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.96 Pain Relevance 0.53
In response to an inflammatory stimulus, PMN migrate into the alveolar compartment as primary effector cells to kill and phagocyte microorganisms.
Localization (migrate) of PMN in phagocyte associated with inflammatory stimuli
11) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.71 Pain Relevance 0.35
Attracted to the lung by IL-8 and leukrotrien B4 PMN secrete MMP-8 and MMP-9.
Localization (secrete) of B4 PMN in lung associated with metalloproteinase
12) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.66 Pain Relevance 0.83
In addition, PMN release granular enzymes (e.g. elastase, cathepsin) and the myeloperoxidase (MPO)-derived oxidant, hypochlorous acid (HOCl).
Localization (release) of PMN associated with urological neuroanatomy
13) Confidence 0.01 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 1.43 Pain Relevance 0.24
Myeloperoxidase (MPO), a heme protein abundantly expressed and secreted by polymorphonuclear neutrophils (PMN), has emerged as a critical mediator in coronary atherosclerosis.
Localization (secreted) of PMN in PMN associated with coronary artery disease and urological neuroanatomy
14) Confidence 0.01 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19362143 Disease Relevance 0.86 Pain Relevance 0
When administered in conjunction with dexamethasone, G-CSF resulted in statistically similar PMN mobilization at dosages of 450 microg and 600 microg.
Localization (mobilization) of PMN
15) Confidence 0.00 Published 2000 Journal Transfusion Section Body Doc Link 10864982 Disease Relevance 0 Pain Relevance 0
CONCLUSION: In a single-dose format designed for clinical granulocyte transfusion programs, optimal PMN mobilization can be achieved in normal donors with a combined regimen of SC G-CSF at 450 microg, and PO dexamethasone at 8 microg.


Localization (mobilization) of PMN in granulocyte
16) Confidence 0.00 Published 2000 Journal Transfusion Section Body Doc Link 10864982 Disease Relevance 0 Pain Relevance 0

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