INT330611

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
plasma membrane (Umod)
Anatomy Link Frequency
macrophages 2
urine 2
Umod (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 39 100.00 Very High Very High Very High
cytokine 20 100.00 Very High Very High Very High
tolerance 5 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 41 100.00 Very High Very High Very High
Diabetes Mellitus 29 50.00 Quite Low
Insulin Resistance 8 50.00 Quite Low
Impaired Glucose Tolerance 6 50.00 Quite Low
Hyperlipidemia 2 50.00 Quite Low
Obesity 33 5.04 Very Low Very Low Very Low
Fabry Disease 18 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Gauchers Disease 7 5.00 Very Low Very Low Very Low
Metabolic Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combined ERT and SRT is most effective at reducing uromodulin levels in the urine of Fabry-Rag mice
Negative_regulation (reducing) of Gene_expression (levels) of uromodulin in urine
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Treatment with the selected active fraction Rx caused a drastic reduction in secretion of pro-inflammatory cytokines including MCP-1 and IL-6 in the conditioned medium of THP-1 macrophages, in a dose-dependent manner (figure 3a, b).
Negative_regulation (reduction) of Gene_expression (macrophages) of THP-1 in macrophages associated with inflammation and cytokine
2) Confidence 0.02 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.39 Pain Relevance 0.35

General Comments

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