INT330612

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.22

cytosol (Inpp5d) plasma membrane (Inpp5d) cytoplasm (Inpp5d)

Anatomy Link Frequency macrophages 2 Inpp5d (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 39 93.48 cytokine 20 77.36 tolerance 5 5.00 withdrawal 3 5.00 chemokine 2 5.00 anesthesia 1 5.00 Inflammatory response 1 5.00 Inflammatory mediators 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 41 93.48 Diabetes Mellitus 29 67.76 Obesity 33 50.40 Insulin Resistance 8 50.00 Impaired Glucose Tolerance 6 50.00 Hyperlipidemia 2 50.00 Metabolic Disorder 6 5.00 Body Weight 3 5.00 Toxicity 1 5.00 Hypoxia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RAW-Blue cells are derived from RAW-264.7 macrophages that stably express a secreted embroyonic alkaline phosphotase (SEAP) gene which can be induced by NF-?

Positive_regulation (induced) of Localization (secreted) of phosphotase in macrophages

1) Confidence 0.02 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.35 Pain Relevance 0.22

General Comments

This test has worked.