INT330696

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1, E2F2) DNA binding (RB1, E2F2) nucleus (RB1, E2F2)
transcription factor binding (RB1, E2F2) molecular_function (RB1) cell division (RB1)
RB1 (Homo sapiens)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 51 100.00 Very High Very High Very High
Cancer 6 96.96 Very High Very High Very High
Infection 11 72.40 Quite High
Osteogenic Sarcomas 2 38.64 Quite Low
Viral Infection 10 5.00 Very Low Very Low Very Low
Epstein-barr Virus 4 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Herpes Zoster 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of Rb on specific Cdk-consensus sites results in the dissociation of protein complexes between Rb, histone deacetylases (HDACs), and E2F transcription factors and allows for the expression of E2F-responsive genes that drive progression through G1 and entry into the S-phase of the cell cycle [64].
Phosphorylation (Phosphorylation) of Rb Positive_regulation (allows) of Gene_expression (expression) of E2F associated with retinoblastoma
1) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 1.00 Pain Relevance 0

General Comments

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