INT330707

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.13 Pain Relevance 0

cytoskeletal protein binding (Anxa2) extracellular region (Anxa2) proteinaceous extracellular matrix (Anxa2) plasma membrane (Anxa2) protein complex (Anxa2) cytoplasm (Anxa2)

Anatomy Link Frequency adipose tissue 1 Anxa2 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 5 5.00 agonist 3 5.00 dexamethasone 2 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Obesity 5 99.76 Atherosclerosis 27 98.56 Cardiovascular Disease 5 97.60 Pressure And Volume Under Development 29 96.52 Metabolic Syndrome 18 92.20 Intrauterine Growth Retardation 3 86.68 Nutritional Deficiencies 4 44.68 Targeted Disruption 4 44.24 Disease 4 21.56 Starvation 5 15.48

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Protein

Mutation

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Anatomy

Negation

Speculation

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Indeed, adipose tissue is able to secrete a number of “adipokines” [17] some of them, like resistin, leptin, adiponectin, Monocyte Chemoattractant Protein-1, Interleukin-6, angiotensinogen, angiotensin-converting enzyme, plasminogen activator inhibitor-1 (PAI-1), being implicated in cardiovascular disease [rev. in 18, 19].

Localization (secrete) of Protein-1 in adipose tissue associated with cardiovascular disease and obesity

1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 1.13 Pain Relevance 0

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