INT3308

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Context Info
Confidence 0.73
First Reported 1978
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 5.32
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1) signal transducer activity (PTGER1)
Anatomy Link Frequency
plaque 1
astrocytes 1
decidua 1
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 17 99.80 Very High Very High Very High
cytokine 27 99.62 Very High Very High Very High
midbrain 4 99.36 Very High Very High Very High
Kinase C 6 94.80 High High
antagonist 1 85.68 High High
cINOD 8 84.08 Quite High
cva 139 83.88 Quite High
Pain 2 76.88 Quite High
peptic ulcer disease 1 73.64 Quite High
COX-2 inhibitor 6 69.12 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 10 98.14 Very High Very High Very High
Disease 41 97.84 Very High Very High Very High
Necrosis 7 96.56 Very High Very High Very High
Cancer 7 96.20 Very High Very High Very High
Body Weight 2 85.44 High High
Cv General 3 Under Development 133 83.88 Quite High
INFLAMMATION 5 83.52 Quite High
Pain 1 76.88 Quite High
Fever 1 74.88 Quite High
Injury 12 69.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data were exported from Epi Info into SAS for windows version 8.00 (SAS statistical software, Cary, NC, USA) for statistical analysis.
Localization (exported) of Epi
1) Confidence 0.73 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.67 Pain Relevance 0.22
The effects of 11-methyl 16,16 dimethyl prostaglandin E2 on gastric acid secretion in man.
Localization (secretion) of TM-PGE
2) Confidence 0.46 Published 1978 Journal Prostaglandins Section Title Doc Link 704919 Disease Relevance 0 Pain Relevance 0.07
LPS and also arachidonic acid (AA) dose-dependently stimulated PGE(2) release.
Localization (release) of PGE
3) Confidence 0.06 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.67 Pain Relevance 0.13
No effects of either plaque-associated cytokines or Abeta(1-42) on PGE(2) secretion were seen, even when cells were co-stimulated with AA, to provide enough substrate.
Localization (secretion) of PGE in plaque associated with abeta and cytokine
4) Confidence 0.06 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.62 Pain Relevance 0.20
To assess functional COX activity, the release of PGE(2) into the culture medium was determined.
Spec (determined) Localization (release) of PGE
5) Confidence 0.06 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.71 Pain Relevance 0.13
COX-2 and in part COX-1-selective inhibitors inhibited LPS-induced PGE(2) secretion, whereas the AA-induced PGE(2) secretion was reduced by COX-1-selective inhibitors only.
Localization (secretion) of PGE
6) Confidence 0.06 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.61 Pain Relevance 0.30
COX isotype selective inhibitors were used to discern relative contributions of COX-1 and COX-2 activities to microglial PGE(2) secretion.
Localization (secretion) of PGE
7) Confidence 0.06 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.62 Pain Relevance 0.29
COX-2 and in part COX-1-selective inhibitors inhibited LPS-induced PGE(2) secretion, whereas the AA-induced PGE(2) secretion was reduced by COX-1-selective inhibitors only.
Localization (secretion) of PGE
8) Confidence 0.06 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.60 Pain Relevance 0.31
Here we show that amyloid beta peptide 25-35 (Abeta(25-35)) induces COX-2 mRNA and protein synthesis and a subsequent release of prostaglandin E(2) (PGE(2)) in primary midbrain astrocytes.
Localization (release) of PGE in astrocytes associated with alzheimer's dementia, midbrain and abeta
9) Confidence 0.01 Published 2006 Journal Neurochem. Int. Section Abstract Doc Link 16546299 Disease Relevance 0.66 Pain Relevance 0.85
In addition, atosiban suppresses OT-mediated release of PGE and PGF from the decidua.79,80

Phase II and III studies

Localization (release) of PGE in decidua
10) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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