INT330875

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PLDN, Ache) endosome (PLDN) nuclear envelope (Ache)
Golgi apparatus (Ache) cytosol (PLDN) pigmentation (PLDN)
Anatomy Link Frequency
brain 2
PLDN (Homo sapiens)
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 12 52.08 Quite High
Neurotransmitter 4 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 26 91.52 High High
Cognitive Disorder 18 86.16 High High
Disorder Of Lipid Metabolism 14 83.40 Quite High
Amnesia 24 63.12 Quite High
Learning Disorders 2 59.28 Quite High
Shock 16 20.56 Low Low
Toxicity 6 5.00 Very Low Very Low Very Low
Dementia 4 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Piracetam (120 mg/kg p.o.) and PA (150, 300 and 600 mg/kg p.o.) significantly (P < 0.01) reduced the levels of AChE, which is considered as an indicator of inhibition of AChE activity in the rat brain after 7 days of treatment.
PA Negative_regulation (reduced) of Gene_expression (levels) of AChE in brain
1) Confidence 0.01 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937319 Disease Relevance 0.40 Pain Relevance 0.03
However, on 14 days of treatment, piracetam (120 mg/kg p.o.) and PA (300 and 600 mg/kg p.o.) significantly (P < 0.01) reduced the levels of AChE, which is considered as an indicator of inhibition of AChE activity [Figure 1].


PA Negative_regulation (reduced) of Gene_expression (levels) of AChE
2) Confidence 0.01 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937319 Disease Relevance 0.45 Pain Relevance 0

General Comments

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