INT330875

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.85 Pain Relevance 0.03

cytoplasm (PLDN, Ache) endosome (PLDN) nuclear envelope (Ache) Golgi apparatus (Ache) cytosol (PLDN) pigmentation (PLDN)

Anatomy Link Frequency brain 2 PLDN (Homo sapiens) Ache (Rattus norvegicus)

Pain Link Frequency Relevance Heat Eae 12 52.08 Neurotransmitter 4 5.00 gABA 2 5.00 depression 2 5.00 withdrawal 2 5.00 anesthesia 2 5.00 Glutamate 2 5.00 Pain 2 5.00 Catecholamine 2 5.00

Disease Link Frequency Relevance Heat Disease 26 91.52 Cognitive Disorder 18 86.16 Disorder Of Lipid Metabolism 14 83.40 Amnesia 24 63.12 Learning Disorders 2 59.28 Shock 16 20.56 Toxicity 6 5.00 Dementia 4 5.00 Decapitation 4 5.00 Aging 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Piracetam (120 mg/kg p.o.) and PA (150, 300 and 600 mg/kg p.o.) significantly (P < 0.01) reduced the levels of AChE, which is considered as an indicator of inhibition of AChE activity in the rat brain after 7 days of treatment.

PA Negative_regulation (reduced) of Gene_expression (levels) of AChE in brain

1) Confidence 0.01 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937319 Disease Relevance 0.40 Pain Relevance 0.03

However, on 14 days of treatment, piracetam (120 mg/kg p.o.) and PA (300 and 600 mg/kg p.o.) significantly (P < 0.01) reduced the levels of AChE, which is considered as an indicator of inhibition of AChE activity [Figure 1].

PA Negative_regulation (reduced) of Gene_expression (levels) of AChE

2) Confidence 0.01 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937319 Disease Relevance 0.45 Pain Relevance 0

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