INT330876

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.45 Pain Relevance 0

cytoplasm (PLDN, Ache) endosome (PLDN) nuclear envelope (Ache) Golgi apparatus (Ache) cytosol (PLDN) pigmentation (PLDN)

PLDN (Homo sapiens) Ache (Rattus norvegicus)

Pain Link Frequency Relevance Heat Eae 6 41.60 Neurotransmitter 2 5.00 gABA 1 5.00 depression 1 5.00 withdrawal 1 5.00 anesthesia 1 5.00 Glutamate 1 5.00 Pain 1 5.00 Catecholamine 1 5.00

Disease Link Frequency Relevance Heat Disease 13 91.52 Cognitive Disorder 9 86.16 Disorder Of Lipid Metabolism 7 72.92 Amnesia 12 63.12 Learning Disorders 1 48.80 Shock 8 20.56 Toxicity 3 5.00 Dementia 2 5.00 Decapitation 2 5.00 Aging 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, on 14 days of treatment, piracetam (120 mg/kg p.o.) and PA (300 and 600 mg/kg p.o.) significantly (P < 0.01) reduced the levels of AChE, which is considered as an indicator of inhibition of AChE activity [Figure 1].

PA Negative_regulation (reduced) of AChE

1) Confidence 0.01 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937319 Disease Relevance 0.45 Pain Relevance 0

General Comments

This test has worked.