INT3309

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1978
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 17.87
Pain Relevance 6.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CP) oxidoreductase activity (CP) extracellular region (CP)
transmembrane transport (CP)
Anatomy Link Frequency
plasma 1
liver 1
neural 1
CP (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 346 100.00 Very High Very High Very High
Pain 216 99.64 Very High Very High Very High
pain pelvic 2 98.28 Very High Very High Very High
rheumatoid arthritis 13 97.88 Very High Very High Very High
Prostatitis 2 97.88 Very High Very High Very High
spinal inflammation 6 96.36 Very High Very High Very High
gABA 29 93.92 High High
Inflammatory response 10 93.64 High High
alcohol 50 92.84 High High
cytokine 10 90.76 High High
Disease Link Frequency Relevance Heat
Pancreatitis 455 100.00 Very High Very High Very High
Cerebral Palsy 43 100.00 Very High Very High Very High
Cystadenoma 21 100.00 Very High Very High Very High
Spasticity 20 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 99.98 Very High Very High Very High
Pain 195 99.64 Very High Very High Very High
Stress 39 99.40 Very High Very High Very High
Chronic Pelvic Pain Syndrome 2 98.46 Very High Very High Very High
Coronary Artery Disease 33 98.28 Very High Very High Very High
Rheumatoid Arthritis 14 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, ceruloplasmin is a ferroxidase that binds copper and converts ferrous to ferric iron, allowing it to bind to transferrin and be transported.
ceruloplasmin Binding (binds) of
1) Confidence 0.47 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.83 Pain Relevance 0.07
To illustrate this absence of habituation, Fig. 2 presents CP oscillations, for one subject, for all trials without vision with and without a noxious heat stimulation.
CP Binding (oscillations) of
2) Confidence 0.37 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.55 Pain Relevance 0.55
The antioxidant system has an important role in protection from the damage of oxidative stress.16,21,23,26 In our study, by measuring the liver tissue catalase, paraoxonase, arylesterase, ceruloplasmin, and lipid hydroperoxide levels, we obtained information about hepatic IR injury.
ceruloplasmin Binding (measuring) of in liver associated with stress and injury
3) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 1.13 Pain Relevance 0.20
19 mol estimated in plasma, by binding to ceruloplasmin and metallothionein [24].
ceruloplasmin Binding (binding) of in plasma
4) Confidence 0.36 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2945467 Disease Relevance 0.48 Pain Relevance 0.13
OBJECTIVES: To evaluate how age and the duration of the condition influence the distress caused by the chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to study how heat and cold influence the symptoms associated with CP/ CPPS as reported by patients afflicted with the condition.
CP Binding (associated) of associated with pain pelvic, prostatitis and chronic pelvic pain syndrome
5) Confidence 0.36 Published 2007 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 17853027 Disease Relevance 0.35 Pain Relevance 0.26
For example, ceruloplasmin is a ferroxidase that binds copper and converts ferrous to ferric iron, allowing it to bind to transferrin and be transported.
ceruloplasmin Binding (bind) of
6) Confidence 0.35 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.83 Pain Relevance 0.07
Therefore, and because of comparable total serum copper concentrations, the non-ceruloplasmin bound copper level is found to be significantly higher in rheumatoid arthritis patients than in the group of ankylosing spondylitis patients.
ceruloplasmin Binding (bound) of associated with spinal inflammation and rheumatoid arthritis
7) Confidence 0.35 Published 1978 Journal Scand. J. Rheumatol. Section Abstract Doc Link 705270 Disease Relevance 1.29 Pain Relevance 0.86
For the standard deviation of the CP, the ANOVAs showed an increased CP standard deviation for the Pain conditions for both axes (ps < 0.05).
CP Binding (deviation) of associated with pain
8) Confidence 0.32 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.54 Pain Relevance 0.54
Furthermore, Haim and colleagues evaluated the association between previous exposure to CP and future coronary risk in patients with CHD.
CP Binding (association) of associated with coronary artery disease
9) Confidence 0.27 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1458355 Disease Relevance 1.23 Pain Relevance 0.03
Subjects were then randomly assigned (via the ABBA procedure [5]) to receive either SOmaxP or CP.
CP Binding (receive) of
10) Confidence 0.17 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0.31 Pain Relevance 0
Extended analysis of the p.T167A variant revealed no association to CP and in functional assays p.T167A showed normal secretion and activity.
CP Neg (no) Binding (association) of
11) Confidence 0.16 Published 2010 Journal Pancreatology Section Body Doc Link 20484962 Disease Relevance 0.15 Pain Relevance 0
CONCLUSIONS: Although the trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene, we found no association between a specific variant or haplotype and CP in our cohort with a high suspicion of genetically determined disease.


CP Neg (no) Binding (association) of
12) Confidence 0.16 Published 2010 Journal Pancreatology Section Body Doc Link 20484962 Disease Relevance 0.11 Pain Relevance 0
However, our observation of an individual with a combination of heterozygous SPINK1 (N34S) and CASR gene (L173P) mutations, who developed chronic pancreatitis, may indicate the specific pathogenetic background of CP within this family.
CP Binding (background) of associated with chronic pancreatitis
13) Confidence 0.13 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.36 Pain Relevance 0.58
Six of nine studies failed to identify a statistically significant association between the SPINK1 N34S polymorphism and alcoholic CP.
CP Binding (association) of associated with chronic pancreatitis
14) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.70 Pain Relevance 0.47
We found that SPINK1 N34S is strongly associated with CP overall (OR 11.00; 95% CI: 7.59–15.93), but the effect of SPINK1 N34S in alcoholic CP (OR 4.98, 95% CI: 3.16–7.85) was significantly smaller than in idiopathic CP (OR 14.97, 95% C.I.?
CP Binding (associated) of associated with chronic pancreatitis
15) Confidence 0.13 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2289874 Disease Relevance 1.13 Pain Relevance 0.89
For each study, we initially evaluated the association of SPINK1 N34S high-risk haplotype with CP separately.
CP Binding (association) of associated with chronic pancreatitis
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.27 Pain Relevance 0.27
Acute exacerbations of CP identified histologically at the time of surgery and alcohol as etiology for CP may be associated more frequently with intractable pain.


CP Binding (associated) of
17) Confidence 0.09 Published 2001 Journal Arch. Pathol. Lab. Med. Section Body Doc Link 11473456 Disease Relevance 0 Pain Relevance 0
In CP and PA specimens, the CCL20 mRNA and protein expression was weak, comparable to matched normal tissues.
CP Binding (specimens) of associated with cystadenoma and chronic pancreatitis
18) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.90 Pain Relevance 0.52
CONCLUSIONS & INFERENCES: Intrapancreatic microenvironment in CP and PCa induces neuroplastic alterations under in-vitro conditions, leading to increased neural density and hypertrophy.
CP Binding (microenvironment) of in neural
19) Confidence 0.07 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 19912545 Disease Relevance 0 Pain Relevance 0
We have identified a GAD1 sequence change G(36)C, which segregates with autosomal recessive spastic CP in 4 affected siblings.
CP Binding (segregates) of associated with spasticity and cerebral palsy
20) Confidence 0.02 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.22 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox