INT33096

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Context Info
Confidence 0.43
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.84
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
platelet 3
blood 2
cleavage 2
leukocyte 1
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 61 100.00 Very High Very High Very High
beta blocker 47 100.00 Very High Very High Very High
aspirin 41 100.00 Very High Very High Very High
bradykinin 28 97.80 Very High Very High Very High
Inflammation 4 96.40 Very High Very High Very High
imagery 9 84.52 Quite High
Potency 4 84.28 Quite High
Calcium channel 7 82.44 Quite High
alcohol 4 82.32 Quite High
Neuropeptide 238 70.44 Quite High
Disease Link Frequency Relevance Heat
Mental Disorders 74 97.80 Very High Very High Very High
Stress 16 97.76 Very High Very High Very High
Splenomegaly 2 97.52 Very High Very High Very High
INFLAMMATION 4 96.40 Very High Very High Very High
Hepatomegaly 2 95.92 Very High Very High Very High
Coronary Heart Disease 2 86.00 High High
Gauchers Disease 60 85.36 High High
Nicotine Addiction 6 84.80 Quite High
Dementia 3 83.72 Quite High
Liver Disease 2 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Univariate statistics revealed that as compared to tertiary care hospital discharge prescriptions there was a gradual attrition of prescriptions of aspirin, beta blockers, ACE inhibitors/ARBs and statins in chronic tertiary care, secondary care, and primary care, respectively (?
Negative_regulation (attrition) of Gene_expression (/) of ACE associated with aspirin and beta blocker
1) Confidence 0.43 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788593 Disease Relevance 0 Pain Relevance 0.29
Univariate statistics revealed that as compared to tertiary care hospital discharge prescriptions there was a gradual attrition of prescriptions of aspirin, beta blockers, ACE inhibitors/ARBs and statins in chronic tertiary care, secondary care, and primary care, respectively (?
Negative_regulation (inhibitors) of Gene_expression (/) of ACE associated with aspirin and beta blocker
2) Confidence 0.43 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788593 Disease Relevance 0 Pain Relevance 0.29
Vasculoprotective effects of ACE-inhibitors
Negative_regulation (inhibitors) of Gene_expression (effects) of ACE
3) Confidence 0.42 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.71 Pain Relevance 0.21
M captopril (to inhibit any ACE cleavage of DAGNPG) in a volume of 200 ?
Negative_regulation (inhibit) of Gene_expression (cleavage) of ACE in cleavage
4) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0.04
At hospital discharge, there were similar prescription rates for aspirin, ACE-inhibitor/ARB, and ?
Negative_regulation (inhibitor) of Gene_expression (prescription) of ACE associated with aspirin
5) Confidence 0.41 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC2082028 Disease Relevance 1.42 Pain Relevance 0.09
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Negative_regulation (decreased) of Gene_expression (levels) of ACE in platelet
6) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
The effects of an inhibitor of angiotensin-converting enzyme (ACE) on the profile of these vasoactive peptides illustrated that the drug affects not only its ACE target for angiotensin production but also results in prominent alteration of the profiles of bradykinin and related peptides that regulate blood pressure (Fig. 5) (29).
Negative_regulation (inhibitor) of Gene_expression (enzyme) of angiotensin-converting in blood associated with bradykinin
7) Confidence 0.22 Published 2010 Journal AAPS J Section Body Doc Link PMC2976990 Disease Relevance 0.15 Pain Relevance 0.47
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Negative_regulation (decreased) of in leukocyte Gene_expression (levels) of ACE in platelet
8) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.
Negative_regulation (inhibitors) of Gene_expression (Synthesis) of angiotensin-converting enzyme associated with enkephalin
9) Confidence 0.05 Published 1985 Journal J. Med. Chem. Section Title Doc Link 2993614 Disease Relevance 0 Pain Relevance 0.53

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