INT33097

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Context Info
Confidence 0.14
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.41
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PHEX) protein modification process (PHEX) Golgi apparatus (PHEX)
endoplasmic reticulum (PHEX) plasma membrane (PHEX) cell-cell signaling (PHEX)
Anatomy Link Frequency
14.1 1
PHEX (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 15 99.52 Very High Very High Very High
Enkephalin 6 95.28 Very High Very High Very High
sodium channel 1 93.20 High High
tetrodotoxin 4 90.56 High High
Potency 2 78.16 Quite High
Opioid 2 20.80 Low Low
Neurotransmitter 4 5.76 Low Low
Glutamate 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 2 98.72 Very High Very High Very High
Targeted Disruption 6 89.20 High High
Pressure And Volume Under Development 1 75.00 Quite High
Cv General 4 Under Development 1 75.00 Quite High
Disease 2 38.56 Quite Low
Syndrome 2 32.80 Quite Low
Amyloid Plaque 2 30.56 Quite Low
Anaemia 2 29.76 Quite Low
Alzheimer's Dementia 2 26.44 Quite Low
Cancer 2 8.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PHEX is a gene that has been shown to be deficient in patients suffering X-linked hypophosphataemic rickets (XLH) [11].
Negative_regulation (deficient) of PHEX associated with rickets
1) Confidence 0.14 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.26 Pain Relevance 0
The majority of the vertebrate M13 peptidases delineate into functionally related clusters representing the PHEX, Kell, ECE-1, ECE-2, ECEL1, neprilysin and MMELLII groups of peptidases (Figure 2 I-V).
Negative_regulation (groups) of PHEX
2) Confidence 0.10 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
Reducing the osmolarity of the medium by decreasing both sodium and chloride concentrations (Hyp) increased GABA efflux 3-fold.
Negative_regulation (decreasing) of Hyp associated with gaba
3) Confidence 0.03 Published 1997 Journal Acta Neurochir (Wien) Section Abstract Doc Link 9204116 Disease Relevance 0.15 Pain Relevance 0.68
The effectiveness of phosphonamidate peptide analogues as inhibitors of rat kidney or human brain metalloendopeptidase (enkephalinase, E.C. 3.4.24.11) and angiotensin-converting enzyme (ACE, 3.4.14.1) has been explored with a series of enkephalin analogues in which the scissile Gly3-Phe4 amide bond has been replaced with a phosphonamidate moiety.
Negative_regulation (inhibitors) of metalloendopeptidase in 14.1 associated with enkephalin
4) Confidence 0.01 Published 1985 Journal J. Med. Chem. Section Abstract Doc Link 2993614 Disease Relevance 0 Pain Relevance 0.13

General Comments

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