INT330985

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9, CYP2C19) oxidoreductase activity (CYP2C9, CYP2C19) endoplasmic reticulum (CYP2C9, CYP2C19)
enzyme binding (CYP2C19)
Anatomy Link Frequency
body 2
CYP2C9 (Homo sapiens)
CYP2C19 (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 25 68.96 Quite High
Serotonin 36 68.24 Quite High
Potency 3 66.96 Quite High
depression 41 34.64 Quite Low
sSRI 41 18.00 Low Low
headache 3 15.36 Low Low
Nortriptyline 4 5.68 Low Low
antidepressant 35 5.00 Very Low Very Low Very Low
Duloxetine 33 5.00 Very Low Very Low Very Low
fluoxetine 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 48 34.64 Quite Low
Diarrhoea 2 21.16 Low Low
Reprotox - General 2 6 17.36 Low Low
Xerostomia 7 15.92 Low Low
Headache 3 15.36 Low Low
Heart Rate Under Development 4 10.20 Low Low
Major Depressive Disorder 27 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug is widely distributed in the body, with low protein binding and a high volume of distribution (see Table 2).118,119 Following oral absorption, venlafaxine undergoes extensive first-pass hepatic metabolism, where conversion to the active metabolite, desvenlafaxine, occurs via demethylation.157 This reaction is mediated by CYP2D6.120 Desvenlafaxine is further metabolized by CYP3A4.122 Other metabolic pathways for venlafaxine include N-demethylation which is probably mediated by CYP3A4.157 CYP2C9 and CYP2C19 isoenzymes may also be involved in the metabolic pathways of both drugs.121
CYP2C9 Positive_regulation (mediated) of Gene_expression (isoenzymes) of CYP2C19 in body
1) Confidence 0.34 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0 Pain Relevance 0.18

General Comments

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