INT331004

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.08

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG) nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)

Anatomy Link Frequency plasma 2 PPIG (Homo sapiens)

Pain Link Frequency Relevance Heat noradrenaline 25 54.24 Serotonin 36 53.52 Potency 3 52.24 depression 41 19.92 sSRI 41 5.00 antidepressant 35 5.00 Duloxetine 33 5.00 fluoxetine 23 5.00 tricyclic antidepressant 22 5.00 monoamine 13 5.00

Disease Link Frequency Relevance Heat Disorders Of Creatine Metabolism 1 25.36 Depression 48 19.92 Diarrhoea 2 6.44 Major Depressive Disorder 27 5.00 Stress 9 5.00 Vomiting 8 5.00 Xerostomia 7 5.00 Reprotox - General 2 6 5.00 Disease 5 5.00 Constipation 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast with desvenlafaxine, the CYP2D6 genetic polymorphism has a significant influence on venlafaxine pharmacokinetics.122 Both drugs may have low potential for drug interactions, because of low protein binding and a relatively weak inhibitory effect on CYP isoenzymes.90,123 Nevertheless, increased plasma levels of imipramine, its metabolite desimipramine,124 and risperidone were associated with concomitant administration of venlafaxine.125 Furthermore, diphenhydramine may alter the disposition of venlafaxine via inhibition of CYP2D6.126 CYP3A4 inducers may enhance the clearance rate of desvenlafaxine.122

Positive_regulation (increased) of Negative_regulation (effect) of CYP in plasma

1) Confidence 0.08 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0 Pain Relevance 0.08

General Comments

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