INT331011

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (ACCS)
Anatomy Link Frequency
hair 2
ACCS (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 2 66.64 Quite High
depression 54 55.24 Quite High
Angina 1 6.40 Low Low
Lasting pain 2 5.00 Very Low Very Low Very Low
biopsychosocial 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
sSRI 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 14 100.00 Very High Very High Very High
Stress 20 98.24 Very High Very High Very High
Coronary Artery Disease 31 95.62 Very High Very High Very High
Obesity 1 93.60 High High
Diabetes Mellitus 2 93.34 High High
Hypertension 2 93.14 High High
Depression 72 66.56 Quite High
Anxiety Disorder 10 49.60 Quite Low
Cv General 3 Under Development 1 6.40 Low Low
Myocardial Infarction 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings may reflect widespread cortisol concentration elevations in our population, as has been seen before.60 Mean concentrations of cortisol in both our groups of patients appear higher compared with concentrations of hair cortisol measured in healthy young subjects.54 The higher average cortisol concentrations in both depressed and nondepressed CAD patients may reflect the ubiquitous presence of cardiovascular risk factors such as hypertension, diabetes, and obesity, which may be inherently associated with HPA axis dysregulation.32,61,62 In addition, all of our CAD patients suffered from a significant event that may have led to ongoing psychosocial stress, another factor that can increase cortisol concentrations in hair.45,53 While having a recent ACS may also be associated with increased cortisol,60 time since ACS was not significantly associated with cortisol concentrations, or perceived stress, suggesting that these elevations persist.
Neg (not) Positive_regulation (increased) of ACS Binding (associated) of in hair associated with stress, acute coronary syndrome, coronary artery disease, diabetes mellitus, obesity and hypertension
1) Confidence 0.18 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938288 Disease Relevance 1.10 Pain Relevance 0.09

General Comments

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