INT331018

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Cyp2a (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 2 55.20 Quite High
antagonist 14 5.00 Very Low Very Low Very Low
Dopamine 10 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
antiarrhythmic agent 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 90 70.88 Quite High
Weight Gain 28 64.36 Quite High
Galactorrhea 2 56.92 Quite High
Obesity 6 52.80 Quite High
Heart Rate Under Development 6 10.60 Low Low
Cognitive Disorder 52 5.00 Very Low Very Low Very Low
Suicidal Behaviour 18 5.00 Very Low Very Low Very Low
Psychosis 18 5.00 Very Low Very Low Very Low
Sleep Disorders 16 5.00 Very Low Very Low Very Low
Myocardial Infarction 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clozapine has a rather complex pharmacokinetic profile, with large interpatient variability and many drug interactions.63 In contrast, olanzapine presents as a medication with a very low incidence of drug interactions, largely as a result of requiring exceedingly high inhibition of CYP450 systems.64 The results of both in vivo65 and in vitro66 experiments suggest that the metabolism of sertindole is principally mediated by CYP3A4 and CYP2D6, and the known variability of these 2 isoenzymes likely contributes to the observed variability in the pharmacokinetics of sertindole.67 In addition, the inhibitory potential of sertindole at CYP2A,68 CYP2D6, and CYP3A469 is relatively modest and not likely to be of any clinical significance in any patients, except for those already taking CYP2D6 inhibitors or those who are poor metabolizers.
Positive_regulation (by) of Localization (sertindole) of CYP2A
1) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938292 Disease Relevance 0.36 Pain Relevance 0.03
Clozapine has a rather complex pharmacokinetic profile, with large interpatient variability and many drug interactions.63 In contrast, olanzapine presents as a medication with a very low incidence of drug interactions, largely as a result of requiring exceedingly high inhibition of CYP450 systems.64 The results of both in vivo65 and in vitro66 experiments suggest that the metabolism of sertindole is principally mediated by CYP3A4 and CYP2D6, and the known variability of these 2 isoenzymes likely contributes to the observed variability in the pharmacokinetics of sertindole.67 In addition, the inhibitory potential of sertindole at CYP2A,68 CYP2D6, and CYP3A469 is relatively modest and not likely to be of any clinical significance in any patients, except for those already taking CYP2D6 inhibitors or those who are poor metabolizers.
Positive_regulation (at) of Localization (sertindole) of CYP2A
2) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938292 Disease Relevance 0.17 Pain Relevance 0

General Comments

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