INT331037

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Hrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 15 99.84 Very High Very High Very High
antagonist 2 92.16 High High
sSRI 4 50.48 Quite High
antidepressant 6 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 36 99.84 Very High Very High Very High
Congenital Anomalies 1 73.88 Quite High
Manic Depressive Disorder 15 52.80 Quite High
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Apnoea 3 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low
Depressive Disorder 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low
Suicidal Behaviour 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with depression show a decrease in H1 receptor binding, and this decrease is correlated with illness severity.34 Therefore, the modulation of histaminergic activity by quetiapine to induce sleep may be related to the reduction of depressive symptoms in these patients.
Negative_regulation (decrease) of H1 receptor Binding (binding) of associated with depression
1) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938299 Disease Relevance 0.69 Pain Relevance 0.23

General Comments

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