INT33105

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Context Info
Confidence 0.60
First Reported 1985
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.61
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (WAS) protein complex assembly (WAS) cytoplasm (WAS)
Anatomy Link Frequency
platelet 2
plasma 1
WAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 42 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
Analgesic 6 99.98 Very High Very High Very High
Morphine 15 99.92 Very High Very High Very High
cannabis 42 99.84 Very High Very High Very High
Opioid 14 99.60 Very High Very High Very High
Cannabinoid receptor 19 99.52 Very High Very High Very High
antagonist 10 99.32 Very High Very High Very High
Cannabinoid 69 99.12 Very High Very High Very High
narcan 2 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 93 99.84 Very High Very High Very High
Psychosis 8 97.68 Very High Very High Very High
Pain 9 96.52 Very High Very High Very High
Disease 4 95.88 Very High Very High Very High
Thromboangitis Obliterans 2 91.92 High High
Myocardial Infarction 2 90.68 High High
Death 5 87.48 High High
Appetite Loss 3 86.60 High High
Vomiting 5 86.20 High High
Opiate Addiction 2 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of THC and CBN was not affected by the narcotic antagonist, naloxone.
Neg (not) Regulation (affected) of THC associated with antagonist, narcan and delta-9-tetrahydrocannabinol
1) Confidence 0.60 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2994117 Disease Relevance 0.16 Pain Relevance 0.64
If cannabis was regulated rather than prohibited, it would be possible to regulate both the amount of cannabidiol and THC in cannabis products to reduce the risk of addiction and psychosis, by balancing the amount of cannabidiol and THC.
Spec (possible) Regulation (regulate) of THC associated with addiction, cannabis and psychosis
2) Confidence 0.39 Published 2010 Journal BMC Med Section Body Doc Link PMC2922074 Disease Relevance 0.72 Pain Relevance 0.61
We investigated the effects of THC on human platelets and the expression of cannabinoid receptors on their cell membranes in this in vitro study.
Spec (investigated) Regulation (effects) of THC in platelets associated with cannabinoid receptor and delta-9-tetrahydrocannabinol
3) Confidence 0.33 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385362 Disease Relevance 0.62 Pain Relevance 0.54
This suggests that opioid systems mediate or modulate some THC effects.
Regulation (modulate) of THC associated with opioid
4) Confidence 0.24 Published 2000 Journal Drug Alcohol Depend Section Abstract Doc Link 10812285 Disease Relevance 0.13 Pain Relevance 0.57
These findings demonstrate for the first time the modulation of the reinforcing effects of THC by an opioid antagonist in a non-human primate model of marijuana abuse.


Regulation (modulation) of THC
5) Confidence 0.23 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 14668977 Disease Relevance 0 Pain Relevance 0
The aim of this study was to measure the analgesic effect of THC, morphine, and a THC-morphine combination (THC-morphine) in humans using experimental pain models.
Regulation (effect) of THC associated with pain, analgesic, delta-9-tetrahydrocannabinol and morphine
6) Confidence 0.22 Published 2003 Journal Pain Section Abstract Doc Link 14499423 Disease Relevance 0.33 Pain Relevance 1.95
The effects of THC (final concentrations 10(-7) to 10(-5) M) on the expression of activated platelet fibrinogen receptor (glycoprotein IIb-IIIa) and P selectin were characterized by flow cytometry.
Regulation (effects) of THC in platelet associated with delta-9-tetrahydrocannabinol
7) Confidence 0.20 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385362 Disease Relevance 0.59 Pain Relevance 0.54
Naltrexone did not alter plasma THC levels.
Neg (not) Regulation (alter) of THC in plasma
8) Confidence 0.20 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12491025 Disease Relevance 0 Pain Relevance 0
The acute affects of Delta(9)-THC were blocked by SR141716A (i.p.) and partially blocked by SR144528 (i.p.).
Regulation (affects) of THC
9) Confidence 0.18 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12235269 Disease Relevance 0.22 Pain Relevance 1.43
A total of 964, 299 and 1152 transcripts were exclusively changed in the COC+, THC+ and PCP+ groups, respectively.
Regulation (changed) of THC
10) Confidence 0.14 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.30 Pain Relevance 0.41
RATIONALE: Many behavioral effects of delta-9-tetrahydrocannabinol (THC), including its discriminative-stimulus effects, are modulated by endogenous opioid systems.
Regulation (modulated) of THC associated with endogenous opioid and delta-9-tetrahydrocannabinol
11) Confidence 0.04 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15619107 Disease Relevance 0 Pain Relevance 0.31
In contrast, overexpression of activated Akt prevented THC effect on tumor progression (Fig. 6G, right panel).
Regulation (effect) of THC associated with cancer
12) Confidence 0.02 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.54 Pain Relevance 0.16

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