INT331105

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
molecular_function (Vmn1r71) cellular_component (Vmn1r71) signal transducer activity (Mc1r)
Vmn1r71 (Mus musculus)
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 140 100.00 Very High Very High Very High
Pain 42 82.80 Quite High
qutenza 48 81.28 Quite High
TRP channel 8 75.60 Quite High
agonist 18 68.40 Quite High
Inflammation 38 61.28 Quite High
tolerance 28 58.20 Quite High
Eae 32 22.32 Low Low
halothane 6 9.44 Low Low
anesthesia 6 8.40 Low Low
Disease Link Frequency Relevance Heat
Nociception 26 94.16 High High
Targeted Disruption 12 91.96 High High
Pain 48 82.80 Quite High
Neuropathic Pain 44 61.92 Quite High
INFLAMMATION 40 61.28 Quite High
Obesity 8 57.28 Quite High
Inflammatory Pain 18 22.32 Low Low
Injury 36 5.00 Very Low Very Low Very Low
Hyperalgesia 26 5.00 Very Low Very Low Very Low
Sprains And Strains 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recessive yellow mice, Mc1re, lack a functional MC1R.
Mc1re Negative_regulation (lack) of MC1R associated with melanocortin 1 receptor
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 0.14 Pain Relevance 1.02
Recessive yellow mice, Mc1re, are homozygous for the Mc1re allele and lack functional Mc1r by virtue of a single base deletion in the Mc1r gene which produces a frameshift at amino acid 183 and truncation of the receptor in the second extracellular loop between transmembrane domains 4 and 5.
Mc1re Negative_regulation (lack) of Mc1r
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 0.50 Pain Relevance 1.05

General Comments

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