INT33111

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Context Info
Confidence 0.23
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 8.82
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Abpa)
Anatomy Link Frequency
brain 2
anterior commissure 1
corpus callosum 1
forebrain 1
hippocampus 1
Abpa (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.16 Very High Very High Very High
amygdala 4 98.80 Very High Very High Very High
opiate 12 97.72 Very High Very High Very High
fibrosis 4 96.96 Very High Very High Very High
Spinal cord 2 92.60 High High
Spontaneous pain 1 88.08 High High
Potency 4 82.88 Quite High
Morphine 2 65.60 Quite High
Inflammation 4 41.44 Quite Low
Chronic pancreatitis 4 36.84 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 208 100.00 Very High Very High Very High
Diabetes Mellitus 532 99.84 Very High Very High Very High
Urological Neuroanatomy 4 98.00 Very High Very High Very High
Osteoid Osteoma 1 97.76 Very High Very High Very High
Cystic Fibrosis 4 96.96 Very High Very High Very High
Cancer 1 96.76 Very High Very High Very High
Ketosis 4 89.72 High High
Hypertrophy 1 89.72 High High
Pain 5 88.08 High High
Ketoacidosis 4 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient was treated with an en-bloc resection and filling with beta-TCP.
beta-TCP Binding (filling) of
1) Confidence 0.23 Published 2008 Journal Nagoya J Med Sci Section Abstract Doc Link 18954031 Disease Relevance 0.61 Pain Relevance 0.09
The 3 techniques give a similar pattern for the [3H]TCP binding distribution and the biochemical study reveals that two distinct binding sites for [3H]TCP exist: one of high affinity (5-10 nM) in the forebrain, which should be responsible for the psychotropic effects and a second one of lower affinity (50-80 nM) in the hindbrain and the spinal cord, which should be involved in the extrapyramidal behavior induced by PCP and congeneers.
TCP Binding (binding) of in forebrain associated with spinal cord
2) Confidence 0.16 Published 1986 Journal Brain Res. Section Abstract Doc Link 3742196 Disease Relevance 0 Pain Relevance 0.11
[3H]thienyl-phencyclidine ([3H]TCP) binds to two different sites in rat brain.
TCP Binding (binds) of in brain
3) Confidence 0.16 Published 1986 Journal Brain Res. Section Title Doc Link 3742196 Disease Relevance 0 Pain Relevance 0.09
Specific [3H]TCP binding was undetectable in anterior commissure and corpus callosum.
TCP Binding (binding) of in anterior commissure
4) Confidence 0.03 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994834 Disease Relevance 0.10 Pain Relevance 0.39
The highest level of [3H]TCP binding was detected in the hippocampus.
TCP Binding (binding) of in hippocampus associated with hippocampus
5) Confidence 0.03 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994834 Disease Relevance 0.09 Pain Relevance 0.38
Quantitative localization of [3H]TCP binding in rat brain by light microscopy autoradiography.
TCP Binding (binding) of in brain
6) Confidence 0.03 Published 1985 Journal Brain Res. Section Title Doc Link 2994834 Disease Relevance 0.08 Pain Relevance 0.36
Mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) [11-15], cystic fibrosis transmembrane regulator (CFTR) [16], cathepsin B (CTSB) [17] and recently, chymotrypsin C (CTRC) [18] genes have been identified to be associated with TCP but they mostly associate with pancreatic exocrine dysfunction.
TCP Binding (associate) of associated with fibrosis, pancreatitis and cystic fibrosis
7) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 2.74 Pain Relevance 0.05
The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance (OR = 1.59, 95% CI = 0.93–2.70, P = 0.09), while, TCF7L2variant showed a statistically significant association between TCP and FCPD patients carrying the 26V allele (OR = 1.69, 95% CI = 1.11–2.56, P = 0.013).


TCP Binding (association) of associated with diabetes mellitus and pancreatitis
8) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 1.93 Pain Relevance 0
No statistically significant association of the SNPs was observed with TCP or FCPD or between carriers and non-carriers of N34S SPINK1 and L26V CTSB mutations.
TCP Neg (No) Binding (association) of associated with diabetes mellitus and pancreatitis
9) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 1.91 Pain Relevance 0
Interestingly, similar analysis using L26V CTSB variant showed a statistically significant association between TCP and FCPD patients carrying the mutant allele compared to those without the variant (OR = 1.69, 95% CI = 1.11–2.56, P = 0.013) (table 4).
TCP Binding (association) of associated with diabetes mellitus and pancreatitis
10) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 1.27 Pain Relevance 0
Specific [3H]TCP binding was undetectable in anterior commissure and corpus callosum.
TCP Binding (binding) of in corpus callosum
11) Confidence 0.01 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994834 Disease Relevance 0.10 Pain Relevance 0.39

General Comments

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