INT331114

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.93
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DURS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 40 99.36 Very High Very High Very High
Inflammation 4 73.76 Quite High
fibrosis 3 68.00 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain scale 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ulcers 261 100.00 Very High Very High Very High
Pain 38 99.36 Very High Very High Very High
Osteomyelitis 3 99.32 Very High Very High Very High
Increased Venous Pressure Under Development 10 98.72 Very High Very High Very High
Systemic Sclerosis 94 98.38 Very High Very High Very High
Sepsis 1 96.80 Very High Very High Very High
Disease 22 92.00 High High
Keloid Scars 1 74.24 Quite High
INFLAMMATION 4 73.76 Quite High
Calcification 3 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Explanations could include (1) the expected result, given no differences in total number of DUs between treatment groups, (2) a lack of sensitivity to change and discriminative value in the current instruments used to assess hand function in SSc and (3) bosentan treatment does not improve pain and disability in spite of the reduction of new DUs.
Gene_expression (reduction) of DUs associated with pain, ulcers and systemic sclerosis
1) Confidence 0.49 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002766 Disease Relevance 1.12 Pain Relevance 0.18
The difference between studies could not be explained by a seasonal effect on the appearance of new DUs due to the different enrolment periods (October–September vs October–February in the first study).
Gene_expression (appearance) of DUs associated with ulcers
2) Confidence 0.44 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002766 Disease Relevance 1.36 Pain Relevance 0.07
Furthermore, DUs are frequently infected and may lead to osteomyelitis, gangrene, autoamputation, and in some cases to septicaemia [7].
Gene_expression (infected) of DUs associated with osteomyelitis, ulcers, increased venous pressure under development and sepsis
3) Confidence 0.08 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2938432 Disease Relevance 1.45 Pain Relevance 0.19

General Comments

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