INT331193

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Atxn3) nucleus (Atxn3) cytoplasm (Atxn3)
Atxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
carbamazepine 1 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 9 99.12 Very High Very High Very High
Frontotemporal Dementia 3 95.72 Very High Very High Very High
Parkinson's Disease 9 94.28 High High
Spinocerebellar Ataxia Type 2 1 92.44 High High
Alzheimer's Dementia 18 59.36 Quite High
Disease 15 52.96 Quite High
Neurodegenerative Disease 16 42.32 Quite Low
Apoptosis 5 31.60 Quite Low
Starvation 6 5.00 Very Low Very Low Very Low
Multiple Sulfatase Deficiency Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCI-779, a rapamycin ester (i.e., an analogue of rapamycin) reduces both mutant huntingtin and ataxin-3 levels, thereby attenuating toxicity in mouse models of HD and SCA3, respectively [68,69].
Negative_regulation (reduces) of Gene_expression (levels) of ataxin-3 associated with toxicity
1) Confidence 0.17 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.73 Pain Relevance 0

General Comments

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