INT331227

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.13 Pain Relevance 0.05

cytoplasm (Becn1, Pink1) mitochondrion (Pink1) Golgi apparatus (Becn1) protein complex (Becn1) response to stress (Pink1) cytosol (Pink1)

Becn1 (Mus musculus) Pink1 (Mus musculus)

Pain Link Frequency Relevance Heat Substantia nigra 1 90.72 carbamazepine 1 5.00 Clonidine 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 9 99.24 Death 4 88.80 Alzheimer's Dementia 18 86.04 Disease 15 67.36 Targeted Disruption 4 42.28 Amyloid Plaque 1 9.16 Frailty 1 8.52 Dementia 1 6.60 Neurodegenerative Disease 16 5.08 Toxicity 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Full-length PINK1 interacts with Beclin 1 and this appears to act as a positive mediator of autophagy.

Beclin 1 Binding (interacts) of PINK1

1) Confidence 0.03 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.13 Pain Relevance 0.05

General Comments

This test has worked.