INT33127

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Context Info
Confidence 0.17
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 28
Disease Relevance 14.04
Pain Relevance 10.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
spinal cord 20
dorsal root ganglion 6
liver 4
neuronal 4
smooth muscle cells 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 59 100.00 Very High Very High Very High
Pain 33 100.00 Very High Very High Very High
dorsal root ganglion 8 100.00 Very High Very High Very High
lidocaine 20 99.98 Very High Very High Very High
qutenza 44 99.68 Very High Very High Very High
diabetic neuropathy 8 99.38 Very High Very High Very High
Hyperalgesia 48 98.56 Very High Very High Very High
anesthesia 13 98.32 Very High Very High Very High
Hippocampus 13 97.60 Very High Very High Very High
Morphine 14 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 22 100.00 Very High Very High Very High
Ganglion Cysts 8 100.00 Very High Very High Very High
Adhesions 5 100.00 Very High Very High Very High
Diabetes Mellitus 149 99.84 Very High Very High Very High
Diabetic Neuropathy 8 99.38 Very High Very High Very High
Nociception 33 99.20 Very High Very High Very High
Leukemia 3 99.16 Very High Very High Very High
Obesity 60 98.98 Very High Very High Very High
Hyperalgesia 56 98.56 Very High Very High Very High
Death 14 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Studies of phosphorylation in rat mast cells (third report)--isolation of calcium-activated, phospholipid, diacylglycerol-dependent protein kinase from rat basophilic leukemia cells (RBL-1 cells)].
Positive_regulation (calcium-activated) of Phosphorylation (phospholipid) of kinase in RBL-1 associated with leukemia
1) Confidence 0.17 Published 1985 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 2995215 Disease Relevance 0.10 Pain Relevance 0.11
We have previously shown that lidocaine increases the phosphorylation of focal adhesion kinase (FAK, a nonreceptor tyrosine kinase playing a role in neuronal plasticity and cell death).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of kinase in neuronal associated with lidocaine, death and adhesions
2) Confidence 0.17 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.20 Pain Relevance 0.60
We have previously shown that lidocaine increases the phosphorylation of focal adhesion kinase (FAK, a nonreceptor tyrosine kinase playing a role in neuronal plasticity and cell death).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of kinase in neuronal associated with lidocaine, death and adhesions
3) Confidence 0.17 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.20 Pain Relevance 0.59
It was concluded that the anesthesia-induced decrease in fructose 2,6-bisphosphate levels results at least in part from increased phosphorylation of 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of kinase associated with anesthesia
4) Confidence 0.17 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6089777 Disease Relevance 0 Pain Relevance 0.17
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
5) Confidence 0.12 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.06 Pain Relevance 0.51
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (induction) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
6) Confidence 0.12 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.08 Pain Relevance 0.56
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (induction) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
7) Confidence 0.12 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.07 Pain Relevance 0.56
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
8) Confidence 0.12 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.06 Pain Relevance 0.51
Following a pain-related stimulus, it is released in the spinal cord, where it activates its high-affinity receptor TrkB, leading to the phosphorylation of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK).
Positive_regulation (Following) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with pain and spinal cord
9) Confidence 0.07 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.34 Pain Relevance 0.45
Following a pain-related stimulus, it is released in the spinal cord, where it activates its high-affinity receptor TrkB, leading to the phosphorylation of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK).
Positive_regulation (leading) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with pain and spinal cord
10) Confidence 0.07 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.34 Pain Relevance 0.45
Following a pain-related stimulus, it is released in the spinal cord, where it activates its high-affinity receptor TrkB, leading to the phosphorylation of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK).
Positive_regulation (leading) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with pain and spinal cord
11) Confidence 0.07 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.33 Pain Relevance 0.41
Following a pain-related stimulus, it is released in the spinal cord, where it activates its high-affinity receptor TrkB, leading to the phosphorylation of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK).
Positive_regulation (Following) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with pain and spinal cord
12) Confidence 0.07 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.34 Pain Relevance 0.41
At SW 3, p-PEA-15, a FADD-ERK binding partner, was also upregulated (51%) as well as the activation of its phosphorylating Akt1 kinase (49%).
Positive_regulation (activation) of Phosphorylation (phosphorylating) of kinase
13) Confidence 0.06 Published 2010 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 19758790 Disease Relevance 0.06 Pain Relevance 0.74
At SW 3, p-PEA-15, a FADD-ERK binding partner, was also upregulated (51%) as well as the activation of its phosphorylating Akt1 kinase (49%).
Positive_regulation (upregulated) of Phosphorylation (phosphorylating) of kinase
14) Confidence 0.06 Published 2010 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 19758790 Disease Relevance 0.06 Pain Relevance 0.75
Additionally, the coordinated phosphorylation of CREB was initiated by the rapid phosphorylation of MAP kinase, as well as other activated protein kinases, such as calcium/calmodulin protein-dependent kinase II (CaM kinase II), protein kinase A and C [6,9,17,22-24].
Positive_regulation (initiated) of Phosphorylation (phosphorylation) of kinase
15) Confidence 0.05 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.08 Pain Relevance 0.46
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (increase) of in dorsal root ganglion Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
16) Confidence 0.04 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.06 Pain Relevance 0.51
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (increase) of in dorsal root ganglion Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
17) Confidence 0.04 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.06 Pain Relevance 0.51
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (induction) of in dorsal root ganglion Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
18) Confidence 0.04 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.07 Pain Relevance 0.56
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (induction) of in dorsal root ganglion Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
19) Confidence 0.04 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.08 Pain Relevance 0.56
JNK phosphorylation in liver, muscle and adipose tissue were increased in septic animals and atorvastatin induced a downmodulation in the phosphorylation of this serine kinase (Fig. 4A–C).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of kinase in liver associated with obesity
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.70 Pain Relevance 0.04

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