INT331273

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT28, KRT39) cytoplasm (KRT28)
KRT28 (Homo sapiens)
KRT39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Visceral Leishmaniasis 564 100.00 Very High Very High Very High
Disease 108 93.04 High High
Communicable Diseases 6 41.64 Quite Low
Bites And Stings 18 25.00 Low Low
Infection 42 5.00 Very Low Very Low Very Low
Malaria 18 5.00 Very Low Very Low Very Low
Mycobacterial Infection 18 5.00 Very Low Very Low Very Low
Splenomegaly 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Anaemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ROC curves also predicted a higher diagnostic accuracy for rK28 compared to rK39.
rK28 Binding (accuracy) of rK39
1) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.48 Pain Relevance 0
We have addressed limitations of the rK39 with a new synthetic polyprotein, rK28, followed by development and evaluation of two new rK28-based RDT prototype platforms.


rK28 Binding (limitations) of rK39
2) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2939046 Disease Relevance 0.66 Pain Relevance 0
We also observed a subset of individual sera with very low reactivity to rK39, but much higher reactivity to rK28.
rK28 Binding (reactivity) of rK39
3) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.18 Pain Relevance 0
From the testing done on ELISA, rK28 was more sensitive and specific than rK39.
rK28 Binding (specific) of rK39
4) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.49 Pain Relevance 0
Our results showed that many of the rK39 low-reactive sera had higher reactivity to rK28 and in some instances to rK26.
rK28 Binding (reactivity) of rK39
5) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.47 Pain Relevance 0
The benefit of using rK28 for VL diagnosis arises from its ability to capture circulating antibodies to 3 Leishmania antigens compared to rK39, which binds antibodies specific to a single antigen.
rK28 Binding (binds) of rK39 associated with visceral leishmaniasis
6) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.45 Pain Relevance 0

General Comments

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