INT331281

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT28) cytoplasm (KRT28)
KRT28 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Visceral Leishmaniasis 282 99.08 Very High Very High Very High
Disease 54 81.48 Quite High
Infection 21 5.00 Very Low Very Low Very Low
Bites And Stings 9 5.00 Very Low Very Low Very Low
Malaria 9 5.00 Very Low Very Low Very Low
Mycobacterial Infection 9 5.00 Very Low Very Low Very Low
Splenomegaly 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Anaemia 3 5.00 Very Low Very Low Very Low
Communicable Diseases 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A synthetic gene, k28, was generated by fusing multiple tandem repeat sequences of the L. donovani haspb1 and k39 kinesin genes to the complete open reading frame of haspb2, thereby increasing antigen epitope density while providing complementing epitopes in the resulting recombinant protein.
Positive_regulation (generated) of k28
1) Confidence 0.33 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.81 Pain Relevance 0
We next sought to determine whether VL sera with low/borderline ELISA reactivity against rK39 could be detected with greater accuracy using rK28.
Positive_regulation (using) of rK28 associated with visceral leishmaniasis
2) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.47 Pain Relevance 0
We observed that a majority of the VL sera tested in this manner had a much higher response to rK28 and in some cases a stronger response to rK26 (Figure 5C).This may be due to the fact that rK28 can capture circulating antibodies against all three component proteins (Haspb1, LdK39, and Haspb2) leading to a more robust signal.
Positive_regulation (response) of rK28 associated with visceral leishmaniasis
3) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.24 Pain Relevance 0

General Comments

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