INT33133

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.09
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2B) plasma membrane (ITGA2B)
Anatomy Link Frequency
platelet 5
CD14 1
vessels 1
red blood cells 1
ITGA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 9 98.72 Very High Very High Very High
aspirin 32 97.40 Very High Very High Very High
antagonist 27 97.28 Very High Very High Very High
Angina 11 96.28 Very High Very High Very High
Cannabinoid receptor 4 94.76 High High
Cannabinoid 1 90.80 High High
agonist 8 84.36 Quite High
Lasting pain 1 79.00 Quite High
cva 4 25.00 Low Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pleural Effusion 4 99.88 Very High Very High Very High
Heart Rate Under Development 26 99.40 Very High Very High Very High
Myeloid Leukemia 6 96.72 Very High Very High Very High
Cv General 3 Under Development 9 96.28 Very High Very High Very High
Myocardial Infarction 10 95.48 Very High Very High Very High
Stroke 2 94.56 High High
Coronary Artery Disease 9 93.76 High High
Angina 2 93.68 High High
Thrombosis 6 92.80 High High
Leukemia 4 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of ligand-induced binding sites on GPIIb-IIIa was increased in patients receiving abciximab.
Positive_regulation (increased) of GPIIb
1) Confidence 0.67 Published 1998 Journal Thromb. Haemost. Section Abstract Doc Link 9869173 Disease Relevance 0.14 Pain Relevance 0.11
We demonstrated significantly increased expression of GP53 and activated GPIIb/IIIa on the platelet surface using a sensitive flow cytometric method of detection.
Positive_regulation (activated) of GPIIb in platelet
2) Confidence 0.67 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735809 Disease Relevance 0.44 Pain Relevance 0.14
M) resulted in a significantly greater inhibition of the percentage of P-selectin positive platelets by 67.3±4.4% and of activated GPIIb/IIIa to 54.2±2.6%.
Positive_regulation (activated) of GPIIb in platelets
3) Confidence 0.49 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0.15
RESULTS: PTCA induced a marked up-regulation of CD18, CD11b, CD14 and GPIIb/IIIa with L-selectin shedding and reduced SO formation, whereas only minor L-selectin down-regulation and decreased SO production indicated activation in UA.
Positive_regulation (up-regulation) of GPIIb in CD14
4) Confidence 0.49 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771923 Disease Relevance 0.15 Pain Relevance 0
In the final 2 weeks changes in fibre intakes were: Gp A, mean increase 7.2 +/- 1.0 g per day (P less than 0.001); Gp B, mean increase 9.1 +/- 1.6 g per day (P less than 0.001); Gp C mean decrease 3.50 +/- 1.6 g per day (P less than 0.005).
Positive_regulation (increase) of Gp B
5) Confidence 0.46 Published 1985 Journal Hum Nutr Appl Nutr Section Abstract Doc Link 2995279 Disease Relevance 0.14 Pain Relevance 0
In the final 2 weeks changes in fibre intakes were: Gp A, mean increase 7.2 +/- 1.0 g per day (P less than 0.001); Gp B, mean increase 9.1 +/- 1.6 g per day (P less than 0.001); Gp C mean decrease 3.50 +/- 1.6 g per day (P less than 0.005).
Positive_regulation (increase) of Gp B
6) Confidence 0.46 Published 1985 Journal Hum Nutr Appl Nutr Section Abstract Doc Link 2995279 Disease Relevance 0.14 Pain Relevance 0
Platelet reactivity was assessed by flow cytometry measurements of P-selectin (CD62P) and activated GpIIb/IIIa complex (PAC-1).
Positive_regulation (activated) of GpIIb in Platelet associated with heart rate under development
7) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.18 Pain Relevance 0.04
The effects of THC (final concentrations 10(-7) to 10(-5) M) on the expression of activated platelet fibrinogen receptor (glycoprotein IIb-IIIa) and P selectin were characterized by flow cytometry.
Positive_regulation (activated) of platelet fibrinogen receptor in platelet associated with delta-9-tetrahydrocannabinol
8) Confidence 0.25 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385362 Disease Relevance 0.57 Pain Relevance 0.57
The cells from pleural effusion were positive for CD7, CD13, CD33, CD41a, including CD33, CD41a-double positive cells in 57.5%.
Positive_regulation (positive) of CD41a associated with pleural effusion
9) Confidence 0.03 Published 1994 Journal Rinsho Ketsueki Section Abstract Doc Link 8139119 Disease Relevance 0.73 Pain Relevance 0.09
The cells from pleural effusion were positive for CD7, CD13, CD33, CD41a, including CD33, CD41a-double positive cells in 57.5%.
Positive_regulation (positive) of CD41a associated with pleural effusion
10) Confidence 0.02 Published 1994 Journal Rinsho Ketsueki Section Abstract Doc Link 8139119 Disease Relevance 0.73 Pain Relevance 0.09
For these reasons, which may confound the interpretation of the functional state of P2Y12, we elected to measure surface translocation of P-selectin as an activation marker possibly more directly linked to ADP-induced platelet stimulation, as well as PAC-1 binding that, by reflecting GP IIb-IIIa activation, provides information consistent with that of aggregation assays.
Positive_regulation (activation) of GP IIb-IIIa in platelet associated with heart rate under development
11) Confidence 0.01 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.10 Pain Relevance 0.04
ADP released from damaged vessels and red blood cells induces platelet aggregation through activation of the integrin GPIIb-IIIa and subsequent binding of fibrinogen.
Positive_regulation (activation) of integrin GPIIb-IIIa in red blood cells
12) Confidence 0.01 Published 2001 Journal Nature Section Abstract Doc Link 11196645 Disease Relevance 0.38 Pain Relevance 0.10
ADP released from damaged vessels and red blood cells induces platelet aggregation through activation of the integrin GPIIb-IIIa and subsequent binding of fibrinogen.
Positive_regulation (activation) of integrin GPIIb-IIIa in vessels
13) Confidence 0.00 Published 2001 Journal Nature Section Abstract Doc Link 11196645 Disease Relevance 0.38 Pain Relevance 0.10

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