INT331335

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.01
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mir483 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 45 89.92 High High
alcohol 18 87.28 High High
Glutamate 45 30.48 Quite Low
Inflammation 18 28.72 Quite Low
Bioavailability 18 21.76 Low Low
addiction 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 162 99.34 Very High Very High Very High
Disease 144 99.00 Very High Very High Very High
American Trypanosomiasis 45 86.68 High High
INFLAMMATION 18 28.72 Quite Low
Parasitic Infection 18 6.64 Low Low
Heart Disease 9 5.00 Very Low Very Low Very Low
Bites And Stings 9 5.00 Very Low Very Low Very Low
Parasitemia 9 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WRR-483, an analog of K11777, was synthesized and evaluated as an inhibitor of cruzain and against T. cruzi proliferation in cell culture.
Gene_expression (synthesized) of WRR-483
1) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2939063 Disease Relevance 0.61 Pain Relevance 0.04
Biological effects of WRR-483
Gene_expression (effects) of WRR-483
2) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.04
In this case, WRR-483 was found to be effective in reducing host invasion by inhibiting the cysteine proteasethat is released by the organism.[39]
Gene_expression (effective) of WRR-483
3) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.08 Pain Relevance 0.04
In this case, WRR-483 was found to be effective in reducing host invasion by inhibiting the cysteine proteasethat is released by the organism.[39]
Gene_expression (found) of WRR-483
4) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.08 Pain Relevance 0.04
Determination of dose response of the activity of WRR-483 against T. cruzi infection in BESM cells demonstrated that WRR-483 had an EC50 of 0.2 ┬ÁM, which was more effective than K11777 and comparable to posaconazole (EC50?
Gene_expression (had) of WRR-483 associated with infection
5) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.39 Pain Relevance 0.03
Herein, we present the synthesis of WRR-483, a small molecule designed as an irreversible cysteine protease inhibitor, and an assessment of its biological activity against cruzain and T. cruzi infection.
Gene_expression (synthesis) of WRR-483 associated with infection
6) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2939063 Disease Relevance 0.75 Pain Relevance 0
Synthesis of WRR-483 (2)
Gene_expression (Synthesis) of WRR-483
7) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.04
Herein, we report the synthesis of WRR-483 (2), the arginine variant of K11777, its remarkable biological properties, and a crystal structure of WRR-483 bound to cruzain.


Gene_expression (synthesis) of WRR-483
8) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.09 Pain Relevance 0
The synthesis of WRR-483 is summarized in Figure 2.
Gene_expression (synthesis) of WRR-483
9) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.04

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