INT331338

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.21 Pain Relevance 0.16

Mir483 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 10 100.00 Inflammation 4 76.76 Glutamate 10 63.00 alcohol 4 5.00 Bioavailability 4 5.00 addiction 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 76.76 Infection 36 58.64 Disease 32 49.40 American Trypanosomiasis 10 5.00 Parasitic Infection 4 5.00 Heart Disease 2 5.00 Bites And Stings 2 5.00 Parasitemia 2 5.00 Body Weight 2 5.00 Death 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also, we have previously demonstrated that WRR-483 is a potent inhibitor of the cathepsin L-like cysteine protease, EhCP1, of E. histolytica, and is much more effective against EhCP1 than K11777. [39] Thus, it is possible that WRR-483 is targeting an as yet unidentified cathepsin L-like cysteine protease in T. cruzi as well.

Localization (targeting) of WRR-483

1) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.03

However, potency of WRR-483 against papain, cathepsins L and V were moderate, and no inhibition of other cysteine proteases, including calpain-1, cathepsins H and K, was observed.

Localization (potency) of WRR-483 associated with potency

2) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.21 Pain Relevance 0.12

General Comments

This test has worked.