INT331338

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mir483 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 10 100.00 Very High Very High Very High
Inflammation 4 76.76 Quite High
Glutamate 10 63.00 Quite High
alcohol 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 76.76 Quite High
Infection 36 58.64 Quite High
Disease 32 49.40 Quite Low
American Trypanosomiasis 10 5.00 Very Low Very Low Very Low
Parasitic Infection 4 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Bites And Stings 2 5.00 Very Low Very Low Very Low
Parasitemia 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, we have previously demonstrated that WRR-483 is a potent inhibitor of the cathepsin L-like cysteine protease, EhCP1, of E. histolytica, and is much more effective against EhCP1 than K11777. [39] Thus, it is possible that WRR-483 is targeting an as yet unidentified cathepsin L-like cysteine protease in T. cruzi as well.
Localization (targeting) of WRR-483
1) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.03
However, potency of WRR-483 against papain, cathepsins L and V were moderate, and no inhibition of other cysteine proteases, including calpain-1, cathepsins H and K, was observed.
Localization (potency) of WRR-483 associated with potency
2) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.21 Pain Relevance 0.12

General Comments

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